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Urine Protein-to-Creatinine Ratio (24-hour collection)

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of protein in your urine compared to a small amount of creatinine (a waste product from muscle breakdown) over a 24-hour period. It helps assess how much protein is being lost in your urine, which can indicate kidney function or other health conditions.

Quick summary

["Helps detect kidney damage or protein loss in urine over time."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
2918-1
Short code
Renin upr Plas-cCnc
Synonyms
Renin upr Plas-cCnc
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Ref low
0
Ref high
2
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Protein in urine can signal kidney problems, such as nephrotic syndrome, diabetic kidney disease, or other chronic conditions. A 24-hour urine collection ensures an accurate total measurement of protein loss, which daily spot tests may miss.

How the Test Works

Your doctor will provide instructions for collecting all urine over 24 hours. The sample is then analyzed to compare protein levels to creatinine levels, providing a ratio that reflects long-term kidney function.

What to Expect Before the Test

No special preparation is needed, but avoid excessive protein-rich foods or certain medications that may affect results. Drink plenty of water to help flush your system.

What to Expect During the Test

You’ll collect all urine in a special container for 24 hours. Return the sample to your lab or clinic on time to ensure accurate results.

Reference range

NCBI: SCC <2.0 ng/mLN/A

Specimen: plasma

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

24-Hour Urine Protein-to-Creatinine Ratio

Frequently asked questions

What causes protein in urine?
Protein in urine can result from kidney damage, infections, high blood pressure, or certain medications. If you notice frequent symptoms like swelling, fatigue, or changes in urine color, talk to your doctor.
How often should I get this test?
Your doctor will determine frequency based on your health history, symptoms, or risk factors. Regular monitoring may be needed if you have kidney disease, diabetes, or high blood pressure.
Can diet affect this test?
Yes—high-protein diets or certain medications (e.g., NSAIDs) may influence results. Follow your doctor’s guidelines for diet and medication adjustments before testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy