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Arterial Blood Carbon Dioxide Partial Pressure (PaCO₂)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of carbon dioxide in your blood taken from an artery, often done during monitoring for breathing or heart conditions.

Quick summary

["Helps assess how well your lungs are removing CO₂ and your body’s acid-base balance."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
76172-6
Short code
Resp rate CO2 meas
Synonyms
Resp rate CO2 meas
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
22
Ref high
28
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
carbon-dioxide-measurement
CPT
82374
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why It’s Done

Your healthcare provider may order this test if you have symptoms like shortness of breath, rapid breathing, chest pain, or if you’re at risk for conditions like respiratory failure, heart disease, or kidney problems. It’s also used during surgeries, intensive care, or before procedures that require deep sedation.

What to Expect

A small needle is inserted into an artery (often in your wrist or arm) to draw a blood sample. You may feel a brief pinch, but the procedure is quick. The test is usually done in a hospital or clinic setting.

Interpretation Basics

Results help determine if your lungs are working properly or if your body is retaining too much CO₂, which can affect your blood pH. Abnormal levels may indicate issues like hyperventilation, lung disease, or metabolic conditions.

Common Conditions Linked to Results

High PaCO₂ levels (hypercapnia) can cause respiratory acidosis, leading to fatigue, confusion, or even coma. Low levels (hypocapnia) may suggest overbreathing or lung overinflation. Your provider will discuss findings in relation to your symptoms and medical history.

Reference range

Adult: 22-28 mmol/LN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

PaCO₂

Frequently asked questions

What does a normal PaCO₂ level mean for me?
A normal PaCO₂ level doesn’t mean your blood chemistry is perfect—it simply indicates that your lungs are removing CO₂ at a typical rate for your body. Your provider will compare it to your overall health and other test results to assess your condition.
How often will I need this test?
The frequency depends on your health status. Some people need it only once, while others (like those with chronic lung disease or heart failure) may have it regularly, sometimes daily or weekly, to monitor their condition closely.
Can I prepare for this test?
No special preparation is needed, but inform your provider about any medications, recent illnesses, or recent procedures that might affect your blood results. Avoid eating or drinking for 2–4 hours before if instructed, though this is less common for arterial blood draws.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy