Hemoglobin Mass Difference in Whole Blood (24-Hour Fluid Collection)
This test measures the change in total hemoglobin mass in your blood over a 24-hour period, often used to assess blood loss or changes in red blood cell production.
["Helps track blood-related conditions by monitoring hemoglobin levels over time."]
Key facts at a glance
- LOINC
- 108287-4
- Short code
- Ret-He-RBC-He (Delta) EntMassDiff Bld
- Synonyms
- Ret-He-RBC-He (Delta) EntMassDiff Bld
- Category
- hematology
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Ref low
- 4.2
- Ref high
- 5.9
- Critical range
- 2 N/A – 7 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 85041
- SNOMED
- 900000000000003001
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your doctor may order this test if they suspect conditions like chronic blood loss (e.g., heavy menstrual bleeding, gastrointestinal bleeding), anemia, or changes in red blood cell production. It can also be part of research studies or specialized clinical evaluations.
What to Expect Before the Test
You’ll need to collect a 24-hour urine sample (or other fluid, depending on protocol) that includes all urine output. Some centers may use whole blood samples instead. Follow your healthcare provider’s instructions precisely to ensure accurate results.
How the Test Works
The test measures hemoglobin mass by analyzing the total amount of hemoglobin in your blood or fluid over time. This is often done using advanced techniques like high-performance liquid chromatography (HPLC) or similar methods to detect small changes in hemoglobin concentration.
What the Results Mean
Results may indicate whether your body is losing or producing hemoglobin at a rate that could affect your health. Abnormal results could signal conditions like iron deficiency, bleeding disorders, or other blood-related issues.
Reference range
Adult males: 4.2-5.9; Females: 3.8-5.1 x 10^12/LN/A
No special preparation required. Stay well hydrated.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: This test is primarily used in research or specialized clinical studies to assess blood-related changes over time. It may complement other tests like hemoglobin A1c or iron studies but is not a routine diagnostic tool for most conditions.
Short name
Hemoglobin Mass Difference (24h)
Frequently asked questions
What does a 'mass difference' in hemoglobin mean?
How is this test different from a standard hemoglobin test?
Can I eat or drink anything before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy