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Red Blood Cell Fetal Hemoglobin Autoantibody Screening

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies that may interfere with measuring fetal hemoglobin (HbF) in your blood, which can affect certain genetic blood disorders like sickle cell disease.

Quick summary

["Autoantibodies can sometimes distort results of fetal hemoglobin tests, so this screening helps ensure accurate diagnosis."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
62249-8
Short code
Retics # Fetus Auto
Synonyms
Retics # Fetus Auto
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
automated-count
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you’re pregnant or planning pregnancy and have a family history of genetic blood disorders, or if you’re experiencing symptoms like fatigue, anemia, or unusual blood test results that suggest abnormal hemoglobin levels. It’s also sometimes used in research or specialized diagnostic settings.

What to Expect Before the Test

No special preparation is needed. You’ll likely have a simple blood draw from a vein in your arm, similar to other routine blood tests. The process is quick and usually painless.

What the Test Measures

This test detects the presence of autoantibodies that could bind to fetal hemoglobin, potentially altering its measurement in your blood sample. The result helps confirm whether these antibodies are affecting your test results.

What the Results Mean

If autoantibodies are found, your healthcare provider may recommend additional testing or further evaluation to rule out conditions like autoimmune disorders or to clarify the cause of abnormal hemoglobin findings.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Fetal Hb Autoantibody Screen

Frequently asked questions

How often does this test cause false results?
Autoantibodies are relatively rare but can occur in some individuals, especially those with autoimmune conditions. If detected, your provider will discuss next steps to ensure accurate diagnosis and avoid misinterpretation of your blood test results.
What if my test shows autoantibodies?
If autoantibodies are present, your healthcare provider may repeat the fetal hemoglobin test using a different method or adjust your diagnostic approach. They may also check for underlying autoimmune conditions or other factors affecting your blood tests.
Does this test require fasting?
No fasting is required for this test. Blood is drawn at any time of day, similar to other standard blood tests.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy