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Reticulin antibody (serum/plasma) concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of antibodies directed against reticulin, a protein found in connective tissue. It may be used to help diagnose conditions affecting connective tissue, such as certain types of fibrosis or autoimmune disorders.

Quick summary

["This test helps assess connective tissue health and potential autoimmune responses."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
57414-5
Short code
Reticulin Ab Ser Ql IF
Synonyms
Reticulin Ab Ser Ql IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you have symptoms or signs of connective tissue disorders, such as joint pain, skin changes, or unexplained fatigue. It may also be used in the evaluation of conditions like systemic sclerosis (scleroderma) or other fibrotic diseases where reticulin plays a role.

What Does the Test Involve?

A blood sample is drawn from a vein, usually in your arm. The blood is then processed to separate the serum or plasma, where the antibody levels are measured using an immunoassay method.

Sample Collection and Preparation

The test requires a simple blood draw. You may feel a brief pinch or discomfort, but it typically takes only a few minutes. The lab processes the sample to isolate the fluid for accurate measurement.

What Are Possible Results?

Results are reported as a concentration of antibodies in the serum or plasma. While specific reference ranges vary by lab, elevated levels may suggest an autoimmune response or connective tissue disorder.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Elevated reticulin antibodies may indicate an underlying autoimmune or fibrotic condition, such as systemic sclerosis or other connective tissue diseases. These antibodies can be part of a broader diagnostic workup to guide treatment and management strategies.

Short name

Reticulin Antibody

Frequently asked questions

What does an elevated or low reticulin antibody level mean?
An elevated level may signal an autoimmune response or connective tissue involvement, but results alone don’t diagnose a condition. Your provider will consider your symptoms, medical history, and other test results for a full evaluation.
How often should I get this test?
Frequency depends on your healthcare plan. Some patients may need retesting if symptoms persist or if their condition is monitored over time, while others may only need it once as part of an initial evaluation.
Can lifestyle changes affect reticulin antibody levels?
While lifestyle factors like diet or exercise may influence overall health, they are less likely to directly impact antibody levels measured in this test. Always follow your provider’s recommendations for managing any underlying conditions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy