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Reticulin Fibers in Serum (Qualitative Immunoassay)

Published: August 9, 2026Updated: August 16, 2026

This test detects the presence of reticulin fibers—a type of protein found in connective tissue—using a serum sample. It helps assess fibrosis or abnormal tissue growth.

Quick summary

["Reticulin fibers may indicate chronic liver disease or other connective tissue disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
108866-5
Short code
Reticulin IgA Msmt Ser
Synonyms
Reticulin IgA Msmt Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test if you have symptoms like fatigue, abdominal discomfort, or signs of liver disease (e.g., jaundice). It’s also used in research or monitoring conditions like cirrhosis or certain cancers.

What Does the Result Mean?

A positive result (detectable reticulin) suggests fibrosis or scarring in tissues. A negative result means no detectable fibers were found in the sample. Results are qualitative, so they’re reported as present or absent.

How Is the Sample Collected?

A blood sample is drawn from a vein, usually in your arm. The serum portion (liquid after clotting) is tested for reticulin fibers using an immunoassay method.

What Are Common Conditions Monitored?

This test is primarily used in research or specialized settings to study connective tissue disorders, fibrosis, or certain cancers. It’s not routinely ordered for general health checks.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Reticulin Fibers (Serum)

Frequently asked questions

What does a positive result mean for my health?
A positive result suggests the presence of reticulin fibers, which may indicate fibrosis or scarring in tissues. Your doctor will discuss this with you in the context of your symptoms and medical history to guide further evaluation.
How often will I need this test?
The frequency depends on your condition and treatment plan. Your healthcare provider will determine if retesting is needed based on your symptoms or monitoring goals.
Can I prepare for this test?
No special preparation is needed. However, avoid alcohol or certain medications that may affect liver function before testing if related to your condition.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy