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Reticulin antibody (serum) – Immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies against reticulin, a protein found in connective tissue. It helps evaluate conditions affecting connective tissue, such as scleroderma or other autoimmune disorders.

Quick summary

["This test may help diagnose or monitor connective tissue diseases."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14273-7
Short code
Reticulin IgA Ser Ql
Synonyms
Reticulin IgA Ser Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms or risk factors for connective tissue disorders, such as persistent joint pain, skin changes, or unexplained fatigue. It could also be used to assess disease activity in conditions like systemic sclerosis (scleroderma).

What to Expect Before the Test

No special preparation is needed. You may have blood drawn from a vein in your arm. If you’re on blood thinners, inform your provider beforehand to avoid unnecessary delays or complications.

What the Test Measures

The test detects antibodies that target reticulin, a structural protein in connective tissues. Elevated levels may suggest an autoimmune response against these proteins, potentially linked to conditions like scleroderma or rheumatoid arthritis.

Possible Results and Interpretation

Results are qualitative (positive/negative) rather than numeric. A positive result indicates the presence of reticulin antibodies, which may support a diagnosis of connective tissue disease. Further testing or clinical correlation is usually required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Reticulin Antibody

Frequently asked questions

Reticulin antibodies are often associated with systemic sclerosis (scleroderma) and other autoimmune connective tissue diseases. While not all positive results confirm a diagnosis, they can guide further evaluation and treatment planning.
A positive result may indicate an autoimmune response against connective tissue, but additional tests and clinical assessment are needed to determine the exact cause and next steps.
How often should I get this test?
The frequency depends on your symptoms, diagnosis, and treatment plan. Your healthcare provider will determine how often to repeat this test based on your individual needs and medical history.
What are the typical reference ranges for this test?
This test is qualitative, meaning it provides a positive or negative result rather than a specific numeric value. Interpretation depends on clinical context and patient symptoms.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy