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Reticulin antibody (serum/plasma) – Immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies against reticulin, a protein found in connective tissue. It helps evaluate conditions affecting connective tissue, such as scleroderma or other autoimmune disorders.

Quick summary

["This test may help diagnose or monitor connective tissue diseases."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
9720-4
Short code
Reticulin IgA Titr Ser
Synonyms
Reticulin IgA Titr Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you have symptoms or a history suggestive of connective tissue disorders, such as joint pain, skin changes, or fatigue. It can also be used to monitor disease activity in certain autoimmune conditions.

What Does the Test Measure?

The test detects antibodies that target reticulin, a protein that supports the structure of connective tissues in your body. Elevated levels may indicate an autoimmune response against these tissues.

How Is the Test Performed?

A blood sample is drawn from a vein in your arm. The sample is processed to separate serum or plasma, which is then analyzed using an immunoassay method to measure antibody levels.

What Are Possible Results?

Results are typically reported as either positive or negative for reticulin antibodies. A positive result suggests an autoimmune reaction against reticulin, which may warrant further evaluation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: This test is primarily used to support a diagnosis of connective tissue diseases like systemic sclerosis (scleroderma) or other autoimmune disorders affecting connective tissues. Elevated antibody levels can help guide treatment decisions and monitor disease progression.

Short name

Reticulin Antibody

Frequently asked questions

What does a positive result mean?
A positive result indicates the presence of reticulin antibodies, which may suggest an autoimmune condition affecting connective tissues. Your healthcare provider will discuss next steps, such as additional testing or treatment options.
Can lifestyle changes affect this test?
Lifestyle factors like diet or stress may influence overall health but are unlikely to directly affect reticulin antibody levels. Follow your provider’s advice for managing symptoms.
How often should I get this test?
Frequency depends on your medical condition and treatment plan. Your provider will determine how often reticulin antibody testing is needed based on your individual care needs.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy