Retinol-binding protein (RBP) in serum/plasma
This test measures the protein that helps transport vitamin A in your blood. It can help assess liver function and vitamin A status.
["RBP supports vitamin A absorption and liver health; low levels may indicate liver disease or vitamin A deficiency."]
Key facts at a glance
- LOINC
- 2921-5
- Short code
- Retinoate SerPl-mCnc
- Synonyms
- Retinoate SerPl-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Matters
Retinol-binding protein (RBP) is a small protein in your blood that carries vitamin A, a fat-soluble nutrient essential for vision, immune function, and cell growth. It’s produced in the liver and helps transport vitamin A to tissues. RBP levels can reflect liver health and vitamin A status, making this test useful in diagnosing conditions like liver disease or vitamin A deficiency.
How the Test Works
Your blood sample is tested using an immunoassay method to detect and quantify RBP. This method identifies the protein’s presence and concentration without measuring vitamin A directly.
Common Reasons for Testing
Doctors may order this test if you have symptoms of liver disease (e.g., fatigue, jaundice), vitamin A deficiency, or if other blood tests suggest liver or nutritional issues. It can also be part of a broader evaluation for malabsorption disorders or metabolic conditions.
What to Expect Before the Test
No special preparation is needed, but avoid alcohol for 24 hours before testing to ensure accurate results. Fasted or non-fasted blood draws are typically acceptable, but check with your provider if you have questions.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
RBP (Serum/Plasma)
Frequently asked questions
What might cause RBP levels to change?
How does RBP relate to vitamin A?
Can RBP test results affect treatment plans?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy