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Retinol-binding protein (RBP) in serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the protein that helps transport vitamin A in your blood. It can help assess liver function and vitamin A status.

Quick summary

["RBP supports vitamin A absorption and liver health; low levels may indicate liver disease or vitamin A deficiency."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
2921-5
Short code
Retinoate SerPl-mCnc
Synonyms
Retinoate SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Retinol-binding protein (RBP) is a small protein in your blood that carries vitamin A, a fat-soluble nutrient essential for vision, immune function, and cell growth. It’s produced in the liver and helps transport vitamin A to tissues. RBP levels can reflect liver health and vitamin A status, making this test useful in diagnosing conditions like liver disease or vitamin A deficiency.

How the Test Works

Your blood sample is tested using an immunoassay method to detect and quantify RBP. This method identifies the protein’s presence and concentration without measuring vitamin A directly.

Common Reasons for Testing

Doctors may order this test if you have symptoms of liver disease (e.g., fatigue, jaundice), vitamin A deficiency, or if other blood tests suggest liver or nutritional issues. It can also be part of a broader evaluation for malabsorption disorders or metabolic conditions.

What to Expect Before the Test

No special preparation is needed, but avoid alcohol for 24 hours before testing to ensure accurate results. Fasted or non-fasted blood draws are typically acceptable, but check with your provider if you have questions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

RBP (Serum/Plasma)

Frequently asked questions

What might cause RBP levels to change?
Low RBP levels can signal liver disease (e.g., cirrhosis, hepatitis), vitamin A deficiency, or malabsorption syndromes like celiac disease. High levels may rarely indicate liver dysfunction or certain genetic conditions, though this is less common. Always discuss results with your healthcare provider.
How does RBP relate to vitamin A?
RBP indirectly reflects vitamin A status because it transports vitamin A in the blood. While RBP alone doesn’t measure vitamin A directly, low RBP can suggest vitamin A depletion, especially in people with liver issues or poor nutrition.
Can RBP test results affect treatment plans?
Yes, if your RBP is low, your doctor may recommend liver function tests, vitamin A supplements, or further evaluation for conditions like liver disease or malabsorption. High RBP may prompt additional testing for underlying metabolic or genetic factors.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy