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Serum Creatinine Phosphokinase (CPK) Isoenzyme Profile (Total CPK)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total activity of Creatine Phosphokinase (CPK), an enzyme found in heart, muscle, and brain tissues. It helps assess muscle damage or heart-related conditions.

Quick summary

["CPK levels can indicate muscle injury or heart stress, guiding treatment decisions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
46437-0
Short code
RF + cCP IgG Pnl Ser-aCnc
Synonyms
RF + cCP IgG Pnl Ser-aCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
86430
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Creatine Phosphokinase (CPK)?

CPK is an enzyme that plays a role in energy production in cells. It exists in different forms (isoenzymes) in various tissues, including heart muscle, skeletal muscle, and brain. When tissues are damaged, CPK leaks into the bloodstream, raising its levels.

Why Is This Test Ordered?

Doctors may order this test to diagnose or monitor conditions like heart attacks, muscle injuries (e.g., from overexertion or trauma), or neurological issues. It can also help evaluate muscle disorders or track recovery after surgery or illness.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab where it is analyzed to measure CPK activity. No special preparation is typically needed, but you may be asked to avoid strenuous activity or certain medications before testing.

What Do Results Mean?

Results are compared to a reference range for your age and health status. Elevated CPK levels may suggest tissue damage, while normal levels indicate healthy tissue function. Your doctor will interpret results in the context of your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

CPK Total (Serum)

Frequently asked questions

What causes elevated CPK levels?
Elevated CPK levels can occur due to muscle damage from exercise, injuries, or conditions like myositis (inflammation of muscles). In the heart, high CPK may signal a heart attack or other cardiac stress. Always discuss symptoms with your healthcare provider.
How long does it take to get results?
Results are usually available within 24 to 48 hours, depending on lab processing times. Your doctor will contact you once results are ready, so check with them for updates.
Can I take anything before the test?
No special preparations are required, but avoid intense physical activity or medications that may affect muscle function 24 hours before testing. Follow your doctor’s instructions for any specific instructions related to your condition.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy