C-reactive protein (CRP) with high-sensitivity measurement
This test measures a protein in your blood that rises when your body is responding to inflammation or infection.
["hs-CRP helps track inflammation, often used alongside other tests to assess risk for conditions like heart disease."]
Key facts at a glance
- LOINC
- 46435-4
- Short code
- RF+cCP IgG Ser-Imp
- Synonyms
- RF+cCP IgG Ser-Imp
- Category
- coagulation
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 86430
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Is hs-CRP Used For?
High-sensitivity CRP (hs-CRP) is primarily used to evaluate the level of systemic inflammation in your body. It can help doctors assess whether you’re at higher risk for conditions like cardiovascular disease, especially if you have risk factors such as high blood pressure, diabetes, or smoking. It may also be used to monitor ongoing inflammation in conditions like rheumatoid arthritis or after certain surgeries.
How Is the Test Performed?
A small blood sample is drawn from a vein, usually in your arm. The blood is processed to separate the serum or plasma, where the CRP protein is measured using a sensitive immunoassay technique. Results are typically available within 24 to 48 hours.
What Does a High or Low Result Mean?
Results are not given in absolute numbers because reference ranges vary by lab and individual factors. A higher-than-normal hs-CRP level may indicate increased inflammation, while a lower level suggests reduced inflammation. Your doctor will interpret results in the context of your overall health and other tests.
Common Reasons for Testing
Your doctor may order hs-CRP testing if you have symptoms of inflammation, risk factors for heart disease, or if you’re undergoing treatment for a chronic condition like arthritis. It can also be used as a screening tool in certain populations to monitor long-term health trends.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: Why It Matters
Short name
hs-CRP
Frequently asked questions
Why might my doctor want to know my hs-CRP level?
What can affect my hs-CRP level?
How often should I get this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy