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C-reactive protein (CRP) with high-sensitivity measurement

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein in your blood that rises when your body is responding to inflammation or infection.

Quick summary

["hs-CRP helps track inflammation, often used alongside other tests to assess risk for conditions like heart disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
46435-4
Short code
RF+cCP IgG Ser-Imp
Synonyms
RF+cCP IgG Ser-Imp
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
86430
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is hs-CRP Used For?

High-sensitivity CRP (hs-CRP) is primarily used to evaluate the level of systemic inflammation in your body. It can help doctors assess whether you’re at higher risk for conditions like cardiovascular disease, especially if you have risk factors such as high blood pressure, diabetes, or smoking. It may also be used to monitor ongoing inflammation in conditions like rheumatoid arthritis or after certain surgeries.

How Is the Test Performed?

A small blood sample is drawn from a vein, usually in your arm. The blood is processed to separate the serum or plasma, where the CRP protein is measured using a sensitive immunoassay technique. Results are typically available within 24 to 48 hours.

What Does a High or Low Result Mean?

Results are not given in absolute numbers because reference ranges vary by lab and individual factors. A higher-than-normal hs-CRP level may indicate increased inflammation, while a lower level suggests reduced inflammation. Your doctor will interpret results in the context of your overall health and other tests.

Common Reasons for Testing

Your doctor may order hs-CRP testing if you have symptoms of inflammation, risk factors for heart disease, or if you’re undergoing treatment for a chronic condition like arthritis. It can also be used as a screening tool in certain populations to monitor long-term health trends.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Why It Matters

Short name

hs-CRP

Frequently asked questions

Why might my doctor want to know my hs-CRP level?
Your doctor may use hs-CRP to help determine if you’re at risk for heart disease, guide treatment decisions for inflammatory conditions, or assess how well a treatment is working. It’s not a diagnostic test for specific diseases but often used alongside other tests to provide a broader health picture.
What can affect my hs-CRP level?
Several factors can influence hs-CRP levels, including recent infections, injuries, stress, smoking, obesity, or certain medications. Avoiding strenuous activity, smoking, or consuming alcohol for 24 hours before the test can help provide more accurate results.
How often should I get this test?
The frequency depends on your health status and doctor’s recommendations. Some people may need hs-CRP tested annually or more often if they have ongoing health concerns or risk factors for inflammation-related conditions.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy