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C-reactive protein (CRP) with high-sensitivity measurement (plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein called C-reactive protein, which your body produces in response to inflammation. It helps assess whether you have low-grade inflammation that may contribute to certain health conditions.

Quick summary

["High-sensitivity CRP helps track subtle inflammation in your body."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
46372-9
Short code
RF Guided BDs PC drn+cath place
Synonyms
RF Guided BDs PC drn+cath place
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
rf
CPT
86430
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to monitor chronic conditions like heart disease, arthritis, or other inflammatory diseases. It can also be used to check for signs of infection or to evaluate how well treatments are working for conditions involving inflammation.

What Does the Test Involve?

A small sample of your blood is drawn from a vein, usually in your arm. The blood is then processed to measure the concentration of C-reactive protein in the plasma portion. This test is typically done in a lab setting.

What Are Common Results?

Results are reported in milligrams per liter (mg/L) or micrograms per milliliter (µg/mL). While specific reference ranges can vary by lab, higher levels often indicate inflammation, and lower levels suggest reduced inflammation.

What Might Affect My Results?

Several factors can influence CRP levels, including recent infections, injuries, smoking, certain medications (like steroids), and underlying health conditions. It’s important to discuss any recent illnesses, treatments, or lifestyle factors with your provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

hs-CRP (plasma)

Frequently asked questions

What does a high CRP level mean?
A high CRP level may signal inflammation in your body, which can be linked to conditions like heart disease, autoimmune disorders, or infections. It’s not always a direct indicator of a specific problem but often helps guide further testing or treatment adjustments.
What does a low CRP level mean?
A low CRP level typically suggests minimal inflammation. However, it doesn’t rule out other conditions entirely. Your provider will consider this result alongside other tests and your overall health to make a diagnosis.
How often should I get this test?
The frequency depends on your medical condition and treatment plan. Your healthcare provider will determine how often you need this test based on your individual needs, such as monitoring chronic diseases or evaluating responses to treatment.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy