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Guided Blood Dye Binding Test (for Alpha-1 Antitrypsin Deficiency Screening)

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein called Alpha-1 Antitrypsin, which helps protect your lungs and liver. Low levels may indicate a genetic condition called Alpha-1 Antitrypsin Deficiency.

Quick summary

["This screening helps identify if you might have a genetic lung or liver condition linked to low Alpha-1 Antitrypsin levels."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
25069-6
Short code
RF Guided Bx
Synonyms
RF Guided Bx
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
rf
CPT
86430
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test checks the amount of Alpha-1 Antitrypsin in your blood. This protein plays a key role in preventing lung damage and liver disease. Low levels can be linked to a genetic disorder that increases your risk of chronic lung diseases like emphysema or liver problems.

Why Might You Need This Test?

Your doctor may recommend this test if you have a family history of Alpha-1 Antitrypsin Deficiency, symptoms of lung issues (like chronic cough or shortness of breath), or liver problems. It’s also used as a screening tool for people with a genetic risk.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood, similar to other routine blood tests. The process usually takes a few minutes.

What Are Possible Results?

Results are typically reported as a ratio or percentage compared to a standard. Low results suggest a higher risk of Alpha-1 Antitrypsin Deficiency. Your doctor will discuss these findings with you and may recommend further testing if needed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Alpha-1 Antitrypsin (A1AT) Screening

Frequently asked questions

What does a low Alpha-1 Antitrypsin level mean?
A low level may indicate Alpha-1 Antitrypsin Deficiency, a genetic condition that can cause lung diseases (like emphysema) or liver problems over time. Your doctor will evaluate your symptoms and family history to determine next steps.
Can this test be used to diagnose Alpha-1 Antitrypsin Deficiency?
This test is often used as a screening tool. If your results are low, further genetic testing may be needed to confirm the diagnosis and guide treatment or management plans.
How often should I get this test?
Your doctor will decide based on your health history, symptoms, and risk factors. Regular monitoring may be recommended if you have a family history of the condition or related health issues.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy