Transcervical fluid (endometrial aspirate) protein concentration (mass concentration)

Why This Test Is Done

Your healthcare provider may order this test if you’re undergoing a procedure like a dilation and curettage (D&C) to check for abnormal uterine bleeding, evaluate uterine health, or investigate symptoms such as pelvic pain or irregularities found on imaging studies. The fluid collected during the procedure is analyzed for protein content as part of a broader diagnostic assessment.

What to Expect Before the Test

No specific preparation is typically required beyond standard pre-procedure instructions (e.g., avoiding certain medications or fasting). You may be asked to empty your bladder before the procedure. Your provider will explain the process and any precautions to take, such as avoiding sexual activity or certain medications.

What Happens During the Test

The test involves inserting a thin tube (cannula) through your cervix into the uterus to collect fluid. This is usually done under local anesthesia to minimize discomfort. The fluid is then sent to a lab for protein analysis. The procedure itself is brief but may cause mild cramping or discomfort.

What the Results Mean

Protein levels in uterine fluid can vary based on the cause of the fluid collection (e.g., diagnostic vs. therapeutic). Elevated or abnormal protein concentrations may signal inflammation, infection, or malignancy, prompting further evaluation. Your provider will discuss results in the context of your symptoms and medical history.