Skip to content

Genetic analysis for RhCE blood group alleles (qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test checks the genetic makeup of your RhCE blood group alleles, which determine certain blood type traits related to red blood cell antigens. It helps ensure compatibility for blood transfusions or pregnancy-related care.

Quick summary

This test helps confirm your blood type compatibility for safe medical procedures.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
46731-6
Short code
RHCE allele Cc Geno Amn
Synonyms
RHCE allele Cc Geno Amn
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Ref low
0
Ref high
5
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
CPT
82378
SNOMED
394995008
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you’re preparing for a blood transfusion, pregnancy, or if you have a family history of Rh-related complications. It’s also used in prenatal care to assess fetal Rh status in Rh-negative mothers.

How the Test Works

A small blood sample is taken from you. The lab analyzes your DNA to identify specific RhCE alleles (C and c variants) using genetic testing methods like next-generation sequencing or targeted PCR. Results indicate whether you carry the C or c allele.

What to Expect Before the Test

No special preparation is needed. You may have a slight bruise or soreness at the needle site, but this is normal. If you’re pregnant, discuss any concerns with your provider before the test.

What the Results Mean

Results show whether you have the RhCE alleles (e.g., RhCE*C/c or RhCE*C/C). This helps determine your Rh blood type (e.g., Rh-positive if you have the C allele) and guides medical decisions like blood donation or fetal monitoring.

Reference range

Non-smokers: <2.5 ng/mL; Smokers: <5.0 ng/mLN/A

Specimen: fluid

No special preparation required. For PSA, avoid sexual activity for 24-48 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is critical for preventing Rh isoimmunization in Rh-negative mothers during pregnancy, where antibodies may develop against the fetus’s Rh-positive blood cells, leading to complications like anemia or stillbirth. It’s also vital for blood compatibility in transfusions and organ transplants.

Short name

RhCE Allele Testing

Frequently asked questions

What does a positive or negative result mean for my blood type?
A positive result for the C allele means you’re Rh-positive (common in most people). A negative result for C (but presence of c) means you’re Rh-negative. Your provider will interpret results in context of your medical history.
How long does it take to get results?
Results are typically available within 1–2 weeks, depending on lab processing times. Your provider will contact you directly with the final report.
Can I donate blood if this test is positive?
Yes, if your RhCE alleles confirm Rh-positive status, you can donate blood. However, your provider may need additional details to ensure compatibility for specific transfusions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy