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Rhesus D Antibody Screening (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of antibodies against the Rhesus D antigen, which can affect blood compatibility during pregnancy or blood transfusions.

Quick summary

["Helps ensure safe blood and pregnancy outcomes by detecting potential immune reactions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
23574-7
Short code
RHDV Ab Ser Ql
Synonyms
RHDV Ab Ser Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

The Rhesus D antigen is a protein found on red blood cells. If your body develops antibodies against it, it can lead to complications during pregnancy (such as Rh incompatibility) or during blood transfusions. This screening helps identify if you have these antibodies early.

When You Might Need It

You may need this test if you are pregnant, have had a previous pregnancy with an Rh-positive baby, have had a blood transfusion, or if you have certain blood disorders. Your healthcare provider will determine if this screening is necessary for your situation.

What to Expect During Testing

A small blood sample is taken from your arm. The sample is then tested to detect antibodies against the Rhesus D antigen using an immunoassay method. Results are typically available within a few days.

Understanding Your Results

If the test is positive, it means you have antibodies against the Rhesus D antigen. This requires further evaluation and may include additional testing or monitoring, especially if you are pregnant or planning pregnancy.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

RHD Antibody Screen

Frequently asked questions

What does a positive result mean?
A positive result means your immune system has detected and produced antibodies against the Rhesus D antigen on red blood cells. This can affect blood compatibility and may require additional medical management, especially during pregnancy.
How often should I get this test?
Your healthcare provider will determine the frequency based on your medical history, current health, and specific circumstances (e.g., pregnancy status). Typically, it may be done once during pregnancy or as needed for monitoring.
Can I prevent a positive result if I am Rh-negative?
If you are Rh-negative and at risk (e.g., during pregnancy), your healthcare provider may administer Rh immune globulin (RhIG) to prevent the formation of antibodies against the Rhesus D antigen. This is a preventive measure, not a cure for existing antibodies.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy