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Rh D Antibody Screening and Titration (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of antibodies against the RhD antigen in your blood, which can affect blood compatibility during transfusions or pregnancy.

Quick summary

["Your blood type and pregnancy history may influence whether this test is needed to prevent complications."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
23576-2
Short code
RHDV Ab Titr Ser IA
Synonyms
RHDV Ab Titr Ser IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Healthcare providers may order this test if you have had a blood transfusion, pregnancy complications, or a blood type mismatch. It helps ensure safe blood transfusions or pregnancy outcomes by detecting unexpected antibodies that could cause problems.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm to draw a blood sample. The test is usually done in a lab setting and may take a few minutes.

What the Test Results Mean

Results are qualitative (positive or negative) and may include a titer value indicating antibody strength. A positive result means antibodies are present, which could affect future blood transfusions or pregnancy care.

Possible Risks and Side Effects

Minor discomfort from the needle stick is common. Rarely, there may be bruising or a slight reaction at the injection site.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

RhD Antibody Test

Frequently asked questions

What causes RhD antibodies to develop?
RhD antibodies may develop after a blood transfusion with Rh-positive blood, pregnancy with an Rh-negative fetus, or previous blood transfusions with mismatched blood.
How often is this test repeated?
Frequency depends on medical history and clinical needs. Some patients may need follow-up tests during pregnancy or after blood transfusions.
Can I stop taking medications before this test?
No medications are typically avoided unless your doctor specifies. Follow your healthcare provider’s instructions for any pre-test preparations.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy