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Rhesus D Antibody Screening (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of antibodies against the Rhesus D antigen, which can affect blood compatibility during pregnancy or transfusions.

Quick summary

["Helps ensure safe blood or pregnancy care by detecting potential risks from Rhesus incompatibility."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
110312-6
Short code
RHDV Ag Msmt Tiss
Synonyms
RHDV Ag Msmt Tiss
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters in Pregnancy

If you’re pregnant or planning pregnancy, this screening is crucial because Rhesus D antibodies can cross the placenta and affect your baby’s blood. Early detection helps healthcare providers take preventive measures, such as Rh immune globulin, to protect your baby from complications like anemia or jaundice.

How the Test Works

A small blood sample is taken from you. The test checks for antibodies (immune proteins) that may have formed against the Rhesus D antigen. If antibodies are found, it indicates your body has been exposed to Rhesus D-positive blood, which can trigger an immune response.

What to Expect During Testing

The process is quick and usually done in a doctor’s office or lab. You may feel a slight pinch when the blood is drawn, but it’s a standard procedure. No special preparation is needed.

Common Reasons for Testing

This test is typically ordered during pregnancy, especially in your first trimester, or if you’ve had a previous pregnancy with complications like miscarriage, stillbirth, or a baby with hemolytic disease.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

RHD Antibody Screen

Frequently asked questions

What does a positive result mean?
A positive result means your blood contains antibodies against the Rhesus D antigen. This is usually harmless unless you become pregnant with a Rhesus D-positive baby, in which case it may require extra monitoring or treatment.
Will I need to take any special steps if my test is positive?
If your test is positive, your healthcare provider will likely recommend regular prenatal care with extra attention to your blood type and baby’s blood type. In some cases, Rh immune globulin may be given during pregnancy to protect future babies.
Can this test be done at home?
No, this test is performed in a clinical lab or doctor’s office. Blood samples are collected by a healthcare professional.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy