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RHD Antibody Screening (Serum/Plasma) by Immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies to the RhD antigen, which can help determine compatibility for blood transfusions or pregnancy-related risks. It’s often used to screen blood donations or assess maternal-fetal Rh incompatibility.

Quick summary

["This test helps ensure safe blood transfusions or check for Rh-related pregnancy risks."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
23581-2
Short code
RHDV Ag Tiss Ql Aggl
Synonyms
RHDV Ag Tiss Ql Aggl
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
aggl
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you’re a blood donor, preparing for a blood transfusion, or experiencing symptoms that could indicate Rh-related complications, such as unexplained anemia or pregnancy complications. It’s also part of routine prenatal screening in some cases.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from a vein in your arm. The sample is sent to a lab for testing.

How the Test Works

The lab uses an immunoassay to detect RhD antibodies in your serum or plasma. If antibodies are present, they’ll react with RhD antigens, triggering a measurable change detected by the test.

What the Results Mean

A positive result means RhD antibodies are present, which may affect blood compatibility or pregnancy outcomes. A negative result means no detectable antibodies are found. Your doctor will discuss results in the context of your medical history and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

RHD Ab Screening

Frequently asked questions

What Does a Positive Result Indicate?
A positive result suggests the presence of RhD antibodies, which could mean you’re at risk for Rh incompatibility—especially if you’re pregnant or planning a blood transfusion. Your doctor will evaluate your situation further and recommend next steps, such as additional testing or monitoring.
Can This Test Be Done at Home?
No, this test requires a lab setting. Blood samples are typically collected by a healthcare professional during a clinic or hospital visit.
How Often Should I Get This Test?
Frequency depends on your medical needs. Your doctor may recommend it during pregnancy (especially first trimester), before blood transfusions, or if you have symptoms like fatigue or jaundice that warrant further investigation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy