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Ribosomal Protein S6 Phosphorylation (Serine Threonine) in CSF

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of phosphorylated ribosomal protein S6 in cerebrospinal fluid (CSF). It may be used to assess certain neurological conditions affecting protein synthesis pathways.

Quick summary

["This test helps evaluate how proteins involved in cell growth and function are regulated in the brain’s fluid."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
109739-3
Short code
Ribosomal P Ab Msmt CSF
Synonyms
Ribosomal P Ab Msmt CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Ref low
44
Ref high
147
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84075
SNOMED
27550007
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why Might This Test Be Ordered?

Your healthcare provider may recommend this test if you have symptoms like cognitive decline, movement disorders, or neurological symptoms that could involve abnormalities in protein metabolism. It may also be part of a broader evaluation for conditions affecting the central nervous system.

What Does the Test Involve?

A small amount of cerebrospinal fluid (CSF) is collected through a procedure called a lumbar puncture (spinal tap). The fluid is then analyzed for the presence and level of phosphorylated ribosomal protein S6.

What Does a Result Mean?

Results are not typically provided as a single numeric range since this is a qualitative or semi-quantitative measure of protein modification. Your provider will interpret the result in the context of your symptoms and other test findings.

Preparation and Procedure Details

No special preparation is usually needed, but you may be asked to fast or avoid certain medications. The procedure involves lying on your side and having a needle inserted into your lower back to collect CSF. You may feel pressure or a mild ache, but it is generally well-tolerated.

Reference range

Adult: 44-147 U/LN/A

Specimen: csf

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Ribosomal Protein S6 Phosphorylation (CSF)

Frequently asked questions

What is the purpose of this test?
This test is used to evaluate how proteins involved in brain cell function are modified in cerebrospinal fluid. It may help diagnose or monitor conditions affecting protein metabolism in the nervous system.
How long does it take to get results?
Results are typically available within a few days to a week, depending on lab processing times. Your healthcare provider will discuss the findings with you during your follow-up visit.
Is there any risk or discomfort involved?
The procedure involves a small risk of headache, infection, or nerve damage, though these are rare. Most people experience minimal discomfort during or after the lumbar puncture.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy