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Rickettsiaiggigmpnlser

Published: August 9, 2026Updated: August 17, 2026

A blood test that detects antibodies against Rickettsia bacteria to diagnose rickettsial infections such as Rocky Mountain spotted fever and typhus.

Quick summary

{"The test uses a blood sample to detect IgG and IgM antibodies against Rickettsia bacteria","IgM antibodies appear first (1-2 weeks after infection), IgG antibodies develop later and indicate past exposure or immunity","Results help doctors diagnose current or recent rickettsial infections, which are treated with antibiotics","Common Rickettsia diseases include Rocky Mountain spotted fever, typhus, and scrub typhus","Early diagnosis and treatment are important as these infections can become serious if left untreated"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
35740-0
Short code
RICKIG
Synonyms
Rickettsia IgG+IgM Pnl Ser
Category
cardiac
Sample
serum
Container
Serum separator tube (SST) or plain red top tube
Units
N/A
Ref low
64
Ref high
128
Critical range
— – 10000 N/A
Fasting
false
Population
adult
Sex
all
Age range
0–120 years
Method
Indirect Immunofluorescence Assay (IFA) or Enzyme-Linked Immunosorbent Assay (ELISA)
CPT
86757 (Rickettsia antibody, IgG); 86758 (Rickettsia antibody, IgM)
SNOMED
122442004 (Rickettsia antibody measurement)
Specimen volume
1-2 mL of serum minimum
Stability
Refrigerated (2-8°C) for up to 7 days; frozen (-20°C or lower) for longer storage up to several months. Avoid repeated freeze-thaw cycles.
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
48–168 hours
Order
routine

What is this test?

The Rickettsia IgG and IgM panel is a blood test that checks for antibodies your immune system produces in response to Rickettsia bacteria. These bacteria are typically transmitted through bites from infected ticks, fleas, or lice. The test measures two types of antibodies: IgM (which appear early in infection) and IgG (which develop later and can indicate past infection or immunity).

Why is this test ordered?

Your doctor may order this test if you have symptoms of a rickettsial infection, especially if you have been exposed to ticks or have recently traveled to areas where these infections are common. Symptoms may include fever, headache, rash (often starting on wrists and ankles), and muscle pain. Early diagnosis is important because these infections can become severe if not treated promptly with antibiotics.

How is the test performed?

A healthcare professional will draw a blood sample from a vein in your arm. The blood is then sent to a laboratory where technicians test it for the presence of Rickettsia-specific IgG and IgM antibodies. You may need to have repeat testing 2-4 weeks apart to look for changes in antibody levels, which helps confirm an active infection.

What do the results mean?

Results are typically reported as positive or negative for IgG and IgM antibodies. A positive IgM result with negative IgG suggests a recent or current infection. Positive IgG (with or without IgM) may indicate a past infection or immunity. Your doctor will interpret these results along with your symptoms, exposure history, and possibly other test results to make a diagnosis.

Reference range

IgG: <1:64 Negative, 1:64-1:128 Equivocal, >1:128 Positive; IgM: <1:32 Negative, 1:32-1:64 Equivocal, >1:64 Positive (for IFA). For ELISA: <0.9 Negative, 0.9-1.1 Equivocal, >1.1 Positive. Titers may vary by laboratory reference standards.N/A

Specimen: serum

No fasting required. No special preparation needed. Collect blood via standard venipuncture into serum separator tube.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

Is fasting required before this test?
No, fasting is not required. You can eat and drink normally before the test. However, follow any specific instructions given by your healthcare provider.
How long does it take to get results?
Results are usually available within 2-5 days, but this may vary depending on the laboratory. Your healthcare provider will inform you when results are ready.
Can this test tell me if I have Rocky Mountain spotted fever?
Yes, this test can help diagnose Rocky Mountain spotted fever and other rickettsial infections. However, because antibodies take time to develop, early in the illness the test may be negative. Your doctor may also consider your symptoms and exposure history for diagnosis.
Do I need to repeat the test?
Sometimes doctors order a second test 2-4 weeks after the first to see if antibody levels have changed. A rising level of antibodies confirms an active infection. Your doctor will determine if repeat testing is necessary.
What happens if my test is positive?
If your test is positive, your doctor will prescribe antibiotics (usually doxycycline) to treat the infection. It's important to start treatment as soon as possible to prevent complications. Most people recover fully with appropriate treatment.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy