Complete Blood Count (CBC) Test: What It Is, Why It Is Done, and What Your Results Mean
A blood test that detects IgM antibodies against Rickettsia bacteria to diagnose spotted fever infections.
{"Detects early immune response to Rickettsia bacterial infections","Helps diagnose spotted fever group infections including Rocky Mountain spotted fever","Performed on a blood serum sample","IgM antibodies appear early in infection and indicate recent or current infection","Results should be interpreted with clinical symptoms and other test results"}
Key facts at a glance
- LOINC
- 110688-9
- Short code
- RFG-IgM
- Synonyms
- Rick SF IgM Msmt Ser
- Category
- cardiac
- Sample
- serum
- Container
- Red top serum tube or Serum Separator Tube (SST)
- Units
- N/A
- Ref low
- 0
- Ref high
- 1
- Critical range
- — – 10000 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- ≥ 0 years
- Method
- Enzyme Immunoassay (EIA)
- CPT
- 86757
- SNOMED
- 186747009
- Specimen volume
- 1.0-2.0 mL serum
- Stability
- Room temperature: 24-48 hours; Refrigerated (2-8°C): 7 days; Frozen (-20°C or below): 30 days
- Hemolysis max
- 50
- Lipemia max
- 100
- Icterus max
- 20
- TAT
- 48–120 hours
- Order
- routine
What is this test? The complete blood count, or CBC, is a common blood test that measures the different cells in your blood, including red blood cells, white blood cells, and platelets, giving your doctor a broad picture of your overall health.
The Rickettsia Spotted Fever Group IgM Antibody test is a blood test that detects IgM (immunoglobulin M) antibodies in your serum. IgM antibodies are the first type of antibodies your immune system produces when fighting a new infection. This test specifically looks for antibodies against bacteria in the Rickettsia genus that cause spotted fever diseases, such as Rocky Mountain spotted fever, Mediterranean spotted fever, and other related infections.
Why do I need this test? Your doctor may order this test as part of a routine checkup, to help find the cause of symptoms such as fatigue, weakness, fever, or easy bruising, to monitor a condition like anemia or infection, or to see how a treatment is affecting your blood cells.
Your healthcare provider may order this test if you have symptoms of a spotted fever infection, especially if you have been exposed to areas where Rickettsia bacteria are common. Symptoms typically include fever, headache, rash (often starting on wrists and ankles), and may include a characteristic dark spot (eschar) at the site of the tick bite. Early detection is important because these infections can become serious if not treated promptly with antibiotics.
How is the test performed? A healthcare professional will draw a small sample of blood from a vein in your arm, usually on the inside of your elbow, using a thin needle. The procedure takes only a few minutes, and you may feel a brief pinch before the sample is sent to a laboratory.
A healthcare professional will draw a small blood sample from a vein in your arm. This sample is then sent to a laboratory where it is analyzed to detect the presence of IgM antibodies specific to Rickettsia spotted fever group bacteria. The test uses specialized laboratory techniques to identify these specific antibodies in your serum.
What do the results mean? Your results show whether your red blood cells, white blood cells, and platelets fall within the normal range. Values that are too high or too low can point to conditions such as anemia, infection, inflammation, or clotting problems, but your doctor will interpret the numbers along with your symptoms and medical history.
A positive result indicates that IgM antibodies against Rickettsia spotted fever group bacteria have been detected in your blood, suggesting a recent or current infection. A negative result means no IgM antibodies were detected, but this does not completely rule out infection, especially if tested very early in the illness. Your healthcare provider will interpret these results together with your symptoms, physical examination, and possibly other tests to make a proper diagnosis.
Reference range
Negative: < 1:64 titer; Equivocal: 1:64 titer; Positive: >= 1:64 titerN/A
No special preparation required. Inform the laboratory of recent travel history, tick exposures, or symptoms such as fever, headache, or rash. Acute and convalescent specimens collected 2-4 weeks apart are recommended for confirmation.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
The Rickettsia Spotted Fever Group IgM Antibody test is important for diagnosing early Rickettsial infections, which can be life-threatening if not treated promptly. Different Rickettsia species cause various spotted fever diseases worldwide, and accurate identification is crucial for appropriate treatment. This test helps differentiate recent infections from past exposures, as IgM antibodies typically appear within the first week of infection and indicate current or recent disease. The test is particularly valuable when clinical symptoms are present but the characteristic rash has not yet appeared.
Frequently asked questions
Is fasting required before this test?
How long does it take to get results?
Can this test tell me exactly which type of Rickettsia caused my infection?
Do I need treatment if my test is positive?
Can the test be positive if I had a past infection?
Sources
- 1
- 2
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy