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ROS1 Gene Mutation Detection (Blood)

Published: August 9, 2026Updated: August 16, 2026

This test checks for specific genetic changes in a protein called ROS1 in your blood, which may help determine if a targeted cancer treatment could be effective for certain types of lung or other cancers.

Quick summary

["This test helps doctors decide if a precision medicine approach may be right for you."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
102038-7
Short code
ROS1 gene Mut Anl Bld/T
Synonyms
ROS1 gene Mut Anl Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may recommend this test if you have certain types of non-small cell lung cancer (NSCLC) or other cancers that show signs of the ROS1 gene rearrangement. It’s also used in cases where standard treatments haven’t worked well.

What to Expect Before the Test

A simple blood sample is taken from a vein in your arm. You may feel a small pinch, but it usually doesn’t cause discomfort. No special preparation is needed.

How the Test Works

The test looks for mutations in the ROS1 gene by analyzing your blood cells. If these mutations are present, they may indicate a genetic alteration that could respond to specific targeted therapies.

What the Results Mean

A positive result means the ROS1 gene mutation is detected, which could guide treatment choices. A negative result means the mutation isn’t found in this sample.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

ROS1 Mutation Test

Frequently asked questions

What does a positive ROS1 mutation mean for my treatment options?
A positive result suggests your cancer may respond to certain targeted drugs designed to block the ROS1 protein. Your doctor will discuss these options with you, including clinical trials or approved therapies that could be tailored to your genetic profile.
How long does it take to get my test results?
Results typically take 1–3 weeks, depending on lab processing times and whether additional testing is needed. Your healthcare team will contact you once results are ready.
Can this test be done on other types of cancer besides lung cancer?
While ROS1 mutations are most commonly studied in lung cancer, they’ve also been found in rare cases of other cancers like thyroid or gastrointestinal tumors. Your doctor will consider the full clinical picture when interpreting results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy