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Serum or plasma concentration of a substance related to donor red blood cell compatibility screening (e.g., antibody detection for transfusion safety)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies in your blood that may react with donor red blood cells, helping ensure safe blood transfusions.

Quick summary

["It helps prevent transfusion reactions by identifying potential red blood cell incompatibilities."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
47360-3
Short code
RPR Ser Donr Ql
Synonyms
RPR Ser Donr Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
rpr
CPT
86592
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order this test if you’re a blood donor or if you’re scheduled for a blood transfusion. It’s also used in certain medical evaluations to assess immune responses related to red blood cell compatibility.

What to Expect Before the Test

You’ll typically provide a blood sample by venipuncture. The test involves collecting serum or plasma, which is then analyzed for specific antibodies that could affect blood compatibility.

What the Test Measures

The test detects the presence and concentration of antibodies (like anti-D or other red blood cell antibodies) that could cause adverse reactions if they react with donor red blood cells during a transfusion.

How the Results Are Used

Results help determine if you’re a suitable donor or if additional testing is needed before a blood transfusion. Positive results may require further evaluation to rule out specific antibody profiles.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

RPR Serology (Donor Screening)

Frequently asked questions

What does a positive result mean?
A positive result indicates the presence of antibodies that may react with donor red blood cells. This doesn’t necessarily mean you’re at immediate risk but may require further testing or donor selection adjustments.
How often should I get this test?
The frequency depends on your medical history, donation status, and healthcare provider’s recommendations. Blood donors may be tested periodically, while others may only need it before a transfusion.
Can I donate blood if I have a positive result?
It depends on the type of antibody detected and your overall health. Your healthcare provider will guide you on eligibility based on the specific findings from this test.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy