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Serum or Plasma Creatinine Concentration (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of creatinine, a waste product from muscle breakdown, in your blood or plasma. It helps assess how well your kidneys are filtering blood.

Quick summary

["A key test for kidney function and overall health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
76643-6
Short code
RR.sd (HR var)
Synonyms
RR.sd (HR var)
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ekg
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Your Kidneys Matter

Your kidneys are vital organs that filter waste and excess substances from your blood, helping to maintain your body’s chemical balance. Creatinine is a byproduct of muscle metabolism that your kidneys remove from your blood. If your kidneys aren’t working well, creatinine levels can build up, which may indicate kidney problems.

What This Test Detects

Creatinine levels in your blood or plasma are measured to determine how efficiently your kidneys are filtering waste. Higher levels may suggest reduced kidney function, while lower levels might indicate overhydration or other conditions.

How the Test Works

A small blood sample is taken from your arm and sent to a lab. The lab uses a specialized method (often automated) to measure creatinine concentration. Results are typically reported in milligrams per deciliter (mg/dL) or millimoles per liter (mmol/L).

What Your Results Mean

Kidney function is often assessed alongside other tests, such as blood urea nitrogen (BUN). While creatinine alone doesn’t diagnose kidney disease, it’s a useful marker when combined with clinical symptoms and other tests. Your doctor will interpret results in the context of your overall health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated creatinine levels can signal kidney damage or disease, especially if accompanied by symptoms like fatigue, swelling, or changes in urine output. Low levels may reflect dehydration or other conditions but are less commonly concerning unless part of a broader evaluation. Regular monitoring is important for people with chronic conditions like diabetes or hypertension.

Short name

Creatinine Level (Serum/Plasma)

Frequently asked questions

What causes creatinine levels to change?
Several factors can influence creatinine levels, including muscle mass (higher muscle = higher creatinine), dehydration, or certain medications. Kidney disease, high blood pressure, or diabetes are common conditions that may lead to elevated levels over time.
Can diet affect creatinine levels?
Dietary changes, such as high-protein intake, can temporarily affect creatinine levels, but they don’t usually alter the long-term interpretation of the test. Your doctor may recommend dietary adjustments if kidney function is compromised.
How often should I get this test?
Frequency depends on your health status. People with kidney disease, diabetes, or high blood pressure may need this test more often, while healthy individuals may only need it periodically as part of routine check-ups.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy