Cerebrospinal Fluid (CSF) Protein by Nephelometry
This test measures the total protein levels in your cerebrospinal fluid, which is the fluid surrounding your brain and spinal cord. It helps assess conditions affecting the central nervous system.
["Measuring CSF protein helps diagnose and monitor neurological conditions."]
Key facts at a glance
- LOINC
- 39581-4
- Short code
- RUBV Ab CSF Ql
- Synonyms
- RUBV Ab CSF Ql
- Category
- chemistry
- Sample
- csf
- Container
- Sterile tube
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 1-2 mL
- Stability
- Immediate analysis required, Refrigerated: 1h
- Hemolysis max
- 200
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your healthcare provider may order this test if you have symptoms like headaches, neurological issues, or signs of inflammation in the brain or spinal cord. It can also be part of a broader evaluation for conditions such as infections, tumors, or multiple sclerosis.
What to Expect Before the Test
No special preparation is usually needed. You may be asked to lie down on your side with your head tilted slightly forward to collect the CSF sample. This is typically done through a procedure called a lumbar puncture (spinal tap).
What Happens During the Test
A healthcare professional will insert a needle into your lower back to collect a small amount of CSF. You may feel pressure or a slight pinch, but the procedure is usually quick and painless. The sample is then sent to the lab for testing.
What the Results Mean
Elevated protein levels in CSF can indicate conditions like infections (e.g., meningitis), inflammation, or certain neurological diseases. Lower than expected levels might suggest bleeding or other abnormalities. Your results will be interpreted by your healthcare provider in the context of your symptoms and medical history.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
CSF protein levels are critical for diagnosing and managing conditions affecting the central nervous system. Elevated proteins often point to increased permeability of the blood-brain barrier or increased production of proteins within the CNS, which can be due to infections, autoimmune diseases, or tumors. Abnormal results guide further testing and treatment planning.
Short name
CSF Protein
Frequently asked questions
What causes abnormal CSF protein levels?
How long does it take to get the results?
Can lifestyle changes affect this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy