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Vitamin D Binding Protein (DBP) Serum Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of vitamin D-binding protein in your blood serum, which helps transport vitamin D and other hormones. It may be used to assess vitamin D metabolism or related conditions.

Quick summary

["Your vitamin D-binding protein levels can reflect broader health about how your body processes certain nutrients and hormones."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
34421-8
Short code
RUBV IgG Avidity Ser-Rto
Synonyms
RUBV IgG Avidity Ser-Rto
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms or conditions linked to vitamin D metabolism, such as unexplained fatigue, bone pain, or certain hormonal imbalances. It could also be part of a broader evaluation for conditions like hypoparathyroidism or kidney function issues.

What to Expect Before the Test

No special preparation is typically needed. You may fast for 8–12 hours before the test if instructed, but always follow your provider’s directions. Bring any medications you’re currently taking to your appointment.

What the Results Mean

Results help determine if your body’s ability to transport vitamin D or other hormones is functioning normally. Abnormal levels may indicate underlying health concerns that need further investigation.

Common Conditions Linked to This Test

While vitamin D-binding protein itself isn’t directly tied to common diseases, elevated or low levels may signal conditions like kidney disease, thyroid disorders, or genetic metabolic syndromes. Your provider will interpret results in the context of your overall health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance: This test is primarily used as a biomarker for assessing vitamin D metabolism and hormone transport. It may be part of a broader diagnostic workup for conditions affecting protein function, electrolyte balance, or endocrine systems, though it does not diagnose specific diseases alone.

Short name

DBP Serum

Frequently asked questions

What does a ‘normal’ result mean for me?
A ‘normal’ result means your vitamin D-binding protein level falls within the expected range for healthy individuals, but it doesn’t guarantee you’re free of related health issues. Your provider will review the result alongside other tests and your medical history to guide next steps.
How often should I get this test?
The frequency depends on your health status. Your provider may recommend it annually or more often if you have conditions like kidney disease, thyroid disorders, or are at higher risk for metabolic imbalances. Follow their guidance.
Can I take supplements before this test?
Avoid vitamin D supplements or multivitamins for at least 48 hours before testing unless directed otherwise. Some medications (like certain diuretics or hormone therapies) may also affect results, so always check with your provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy