Cerebrospinal fluid (CSF) protein concentration by nephelometry

Why This Test Is Done

Your doctor may order this test if you have symptoms like severe headaches, neck stiffness, confusion, or neurological problems. It’s also used to diagnose conditions such as meningitis, multiple sclerosis, or subarachnoid hemorrhage. Sometimes, it’s part of a routine check for conditions affecting the brain or spinal cord.

What to Expect Before the Test

You’ll likely have a small needle inserted into your back to collect a sample of CSF. This is usually done in a hospital or clinic setting. You may feel mild discomfort, but it’s quick and doesn’t require fasting.

What the Results Mean

Normal protein levels in CSF are generally lower than in blood. Elevated levels can indicate inflammation, infections, or bleeding near the brain/spinal cord. Very low levels might suggest certain genetic disorders or other rare conditions.

Common Conditions Linked to Abnormal Results

High protein levels can be seen in conditions like meningitis, multiple sclerosis, or brain tumors. Low protein levels may be linked to conditions like cerebral protein-losing enteropathy or certain genetic disorders. Your doctor will interpret results in the context of your symptoms and medical history.