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Rufinamide/Creatinine Ratio, Urine — Calculated

Published: August 9, 2026Updated: August 16, 2026

This urine test measures rufinamide relative to creatinine to help evaluate drug exposure and treatment adherence while accounting for urine concentration.

Quick summary

["The result can help clinicians assess whether rufinamide exposure is too low, too high, or changing."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
87768-8
Short code
Rufinamide/Creat Ur Cfm
Synonyms
Rufinamide/Creat Ur Cfm
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
confirm
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures the amount of rufinamide in urine and compares it with the amount of creatinine. Creatinine is used as a reference because its urine level varies with urine concentration.

Why might I need this test?

Rufinamide is an antiseizure medicine. This test may be used during treatment monitoring to help assess medication exposure, response, and adherence, especially when blood testing is not available or when a clinician wants an additional measure of drug elimination.

How is the test performed?

A urine specimen is collected and analyzed in a laboratory. The laboratory calculates the rufinamide-to-creatinine ratio from the measured concentrations. The test is generally performed using a random urine sample unless your clinician requests a timed collection.

How do I prepare for the test?

Follow your clinician's instructions about when to collect the urine. Record the date, time, and approximate time of your last rufinamide dose, and tell the laboratory about all medicines you are taking. The sample should be collected in the container provided and labeled as instructed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine rufinamide/creatinine ratio

Frequently asked questions

Is this the same as a urine drug screen?
Not necessarily. A urine drug screen looks for the presence of substances, while this test specifically measures rufinamide and calculates its relationship to urine creatinine.
Why is creatinine included in the result?
Urine can vary greatly in concentration. Creatinine provides a reference that helps account for differences in dilution between urine samples.
Does a low or high result mean my seizure medicine is not working?
Not by itself. The ratio must be interpreted with your dose, when the sample was collected, seizure control, and other clinical information. Your clinician should explain what the result means for you.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy