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S100 Calcium Binding Protein (S100C) in Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the concentration of S100 calcium-binding protein in your blood. It may be used to assess certain conditions affecting nerve or muscle cells.

Quick summary

["S100C helps monitor conditions linked to tissue damage or inflammation in nerves or soft tissues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
100795-4
Short code
S100 Ca binding protein B Fld-mCnc
Synonyms
S100 Ca binding protein B Fld-mCnc
Category
electrolyte
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is S100C Used For?

Doctors may order this test to evaluate conditions such as nerve damage (neuropathy), certain types of muscle disorders, or to monitor progression of diseases like multiple sclerosis or certain cancers that affect soft tissues. It can also help track response to treatment in some cases.

How Is the Sample Collected?

A blood sample is drawn from a vein, usually in your arm. After drawing blood, a band will be applied to your arm to stop any bleeding. You may feel a brief pinch when the needle is inserted, but the procedure is quick.

What Does a Result Mean?

Results are not typically provided as absolute values in this test due to variability in conditions and methods. Your healthcare provider will interpret the result in the context of your overall health and symptoms. Elevated levels may suggest tissue damage or inflammation, while lower levels may indicate normal or less affected tissue.

Common Conditions Monitored

This test is often used alongside other diagnostic tests to help diagnose or manage conditions like peripheral neuropathy, certain types of muscle disorders, or to assess metastatic disease in soft tissues. It may also be part of a broader evaluation for inflammatory or autoimmune conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: S100C Protein Levels Reflect Tissue Damage or Inflammation

Short name

S100C Protein Level

Frequently asked questions

Why might my doctor request this test?
Your doctor may recommend this test if you have symptoms like nerve pain, muscle weakness, or unexplained weight loss. It can also be used to monitor conditions like multiple sclerosis, certain cancers, or chronic inflammation affecting soft tissues.
What are the typical reference ranges for this test?
Reference ranges can vary by lab and method. Since this test measures protein concentration in a complex biological context, your results will be evaluated alongside your clinical picture rather than compared to a single numeric range.
Can I influence my S100C test results?
Avoid strenuous exercise, trauma, or infections before the test as they may temporarily affect protein levels. Follow your doctor’s instructions for fasting or other preparations if required.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy