S100 Calcium Binding Protein (S100C) in Serum/Plasma
This test measures the concentration of S100 calcium-binding protein in your blood. It may be used to assess certain conditions affecting nerve or muscle cells.
["S100C helps monitor conditions linked to tissue damage or inflammation in nerves or soft tissues."]
Key facts at a glance
- LOINC
- 100795-4
- Short code
- S100 Ca binding protein B Fld-mCnc
- Synonyms
- S100 Ca binding protein B Fld-mCnc
- Category
- electrolyte
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Is S100C Used For?
Doctors may order this test to evaluate conditions such as nerve damage (neuropathy), certain types of muscle disorders, or to monitor progression of diseases like multiple sclerosis or certain cancers that affect soft tissues. It can also help track response to treatment in some cases.
How Is the Sample Collected?
A blood sample is drawn from a vein, usually in your arm. After drawing blood, a band will be applied to your arm to stop any bleeding. You may feel a brief pinch when the needle is inserted, but the procedure is quick.
What Does a Result Mean?
Results are not typically provided as absolute values in this test due to variability in conditions and methods. Your healthcare provider will interpret the result in the context of your overall health and symptoms. Elevated levels may suggest tissue damage or inflammation, while lower levels may indicate normal or less affected tissue.
Common Conditions Monitored
This test is often used alongside other diagnostic tests to help diagnose or manage conditions like peripheral neuropathy, certain types of muscle disorders, or to assess metastatic disease in soft tissues. It may also be part of a broader evaluation for inflammatory or autoimmune conditions.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: S100C Protein Levels Reflect Tissue Damage or Inflammation
Short name
S100C Protein Level
Frequently asked questions
Why might my doctor request this test?
What are the typical reference ranges for this test?
Can I influence my S100C test results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy