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Serum or Plasma Bilirubin (Total)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of bilirubin, a yellow pigment produced when red blood cells break down. It helps assess liver function and detect conditions like jaundice or bile duct blockages.

Quick summary

["Bilirubin helps identify liver or bile flow issues and monitor red blood cell health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
71853-6
Short code
SaO2 DF Bld
Synonyms
SaO2 DF Bld
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to check for liver problems, such as hepatitis, cirrhosis, or bile duct obstructions. It can also help diagnose conditions like Gilbert’s syndrome or monitor treatment for hemolytic anemia.

What to Expect Before the Test

No special preparation is needed. You may have a blood draw from a vein in your arm. If you’re on a blood thinner, let your doctor know before the test.

What the Results Mean

Higher than normal levels may indicate liver disease, bile duct issues, or red blood cell breakdown. Lower levels are less common but could signal liver problems or certain genetic conditions.

Common Conditions Monitored

This test is often used alongside others (like direct bilirubin or liver enzymes) to diagnose jaundice, liver inflammation, or blockages in the bile system.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated bilirubin is often the first sign of jaundice, where the skin or eyes turn yellow. It can also signal liver disease, gallbladder issues, or blood disorders. Doctors use these results to guide treatment, such as medications, diet changes, or further testing (like ultrasound or MRI).

Short name

Total Bilirubin

Frequently asked questions

What causes bilirubin levels to rise?
Bilirubin levels can rise due to liver problems (like hepatitis), blocked bile ducts, or when red blood cells break down faster than the liver can process them (e.g., in anemia or blood disorders).
How long does it take to get results?
Results are typically available within 1–3 business days, depending on your lab. Your doctor will discuss them with you during your follow-up visit.
Can diet affect bilirubin levels?
Dietary changes alone rarely affect bilirubin levels, but certain foods (like high-fiber or cruciferous vegetables) may influence liver function indirectly. Always follow your doctor’s advice for dietary guidance if needed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy