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Sarcosine/Creatinine Ratio, Urine

Published: August 9, 2026Updated: August 16, 2026

A urine test that measures sarcosine relative to creatinine. It can help evaluate suspected sarcosinemia and related metabolic conditions.

Quick summary

["An elevated urine sarcosine-to-creatinine ratio may suggest a metabolic disorder but requires confirmation with other tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
28610-4
Short code
Sarcosine/Creat Ur-Rto
Synonyms
Sarcosine/Creat Ur-Rto
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures the amount of sarcosine in urine relative to the amount of creatinine. Sarcosine is an amino acid found in the body, and the ratio helps account for differences in urine concentration.

Why might I need this test?

The test may be ordered when an infant or child has unexplained developmental concerns, seizures, unusual behavior, or other signs that raise concern for an inherited metabolic disorder. It is also used in follow-up of people with suspected or confirmed sarcosinemia.

How is the test performed?

A urine sample is collected and analyzed in a laboratory. The laboratory measures sarcosine and creatinine, then calculates the sarcosine-to-creatinine ratio.

How do I prepare for the test?

Follow the collection instructions provided by your healthcare professional or laboratory. The timing and type of urine collection may vary, so tell the laboratory if the patient is taking medications or receiving dietary or metabolic treatment.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine Sarcosine/Creatinine Ratio

Frequently asked questions

What does the sarcosine-to-creatinine ratio measure?
It compares the amount of sarcosine with the amount of creatinine in urine. Creatinine is used as a marker of urine concentration, helping reduce the effect of variations in how dilute the urine is.
Is this the same as a standard creatinine test?
No. A standard creatinine test measures creatinine alone, while this test reports the ratio of sarcosine to creatinine. The purpose and interpretation are different.
Does an abnormal result confirm sarcosinemia?
No. An elevated result can suggest a problem with sarcosine metabolism, but diagnosis usually requires additional laboratory studies, genetic testing, and clinical evaluation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy