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SARS-CoV-2 Antibody Profile (Nucleocapsid Protein) - Screening and Confirmation

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies to the SARS-CoV-2 virus, specifically targeting the nucleocapsid protein, which helps identify past infection with COVID-19.

Quick summary

["This test can help determine if your immune system has recognized and fought off the virus that causes COVID-19."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
96118-5
Short code
SARS-CoV-2 Ab Pnl DBS IA
Synonyms
SARS-CoV-2 Ab Pnl DBS IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test measures the presence of antibodies produced by your immune system in response to the nucleocapsid protein of SARS-CoV-2. Antibodies are proteins that your body makes to recognize and fight specific viruses. If you have antibodies to this protein, it suggests your immune system has encountered the virus before, likely from a past infection.

How the Test Works

The test uses a combination of immunoassay methods to detect antibodies in your blood. This includes screening tests that identify potential antibodies and confirmation tests to verify their presence and specificity. The nucleocapsid protein is a key target because it is consistently expressed in the virus and helps ensure accurate detection of past infection.

Sample Collection and Preparation

A blood sample is collected from a vein in your arm. The blood is then processed to separate the serum or plasma, which contains the antibodies being tested. This sample is sent to a laboratory for analysis.

When You Might Need This Test

This test may be recommended if you have had symptoms of COVID-19, have been exposed to the virus, or if you are part of a study or screening program focused on monitoring antibody responses.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

SARS-CoV-2 Antibody Test (Nucleocapsid)

Frequently asked questions

How long does it take to get the results of this test?
Results from this test are typically available within a few days to a couple of weeks, depending on the laboratory’s processing schedule and whether the test is part of a screening or confirmatory process.
Can this test tell me if I currently have COVID-19?
No, this test is designed to detect antibodies produced after a past infection, not to diagnose an active COVID-19 infection. For current infection, you would need a different type of test, such as a nucleic acid amplification test (NAAT) or antigen test.
Are antibody tests always accurate?
While antibody tests are generally reliable, they can have some limitations. Factors such as the timing of testing after infection, the presence of other infections, or individual immune responses can affect results. It is always best to discuss the results with your healthcare provider for personalized interpretation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy