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SARS-CoV-2 Immunoglobulin G (IgG) Antibody Test by Titer (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of IgG antibodies in your blood that your immune system produces in response to exposure to the virus that causes COVID-19.

Quick summary

["IgG antibodies indicate past infection or immunity from COVID-19."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
95429-7
Short code
SARS-CoV-2 IgG Titr SerPl IF
Synonyms
SARS-CoV-2 IgG Titr SerPl IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
8
Ref high
61
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
CPT
82977
SNOMED
3110003
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

IgG antibodies are a type of antibody your body makes after recovering from an infection or after vaccination. They provide long-term immunity. This test checks the concentration of these antibodies in your serum or plasma to determine if your immune system has recognized and responded to the SARS-CoV-2 virus.

Why Might You Need This Test?

Your healthcare provider may order this test if you have had COVID-19 symptoms, suspect past exposure, or if you are recovering from COVID-19 to assess your immune response. It can also be used in research or clinical studies to track immunity.

Sample Collection and Preparation

A blood sample is taken from a vein in your arm. The blood is processed to separate serum or plasma, which is then tested for IgG antibodies. This process helps ensure accurate measurement of the antibodies in your system.

What Does a Positive Result Mean?

A positive result means your body has produced IgG antibodies against the SARS-CoV-2 virus, suggesting you have likely had an infection at some point or have been vaccinated. However, IgG alone does not confirm current infection; it indicates past exposure or immunity.

Reference range

Adult males: 8-61 U/L; Adult females: 5-36 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

IgG antibodies are crucial for long-term immunity against COVID-19. High levels may indicate a strong immune response, potentially offering protection against future infections. However, antibody levels can vary and may not always correlate directly with protection over time. This test can help guide decisions about vaccination, exposure assessment, or monitoring immunity in clinical settings.

Short name

IgG Antibody to SARS-CoV-2

Frequently asked questions

How Long Does It Take to Get Results?
Results are typically available within 24 to 48 hours, depending on the laboratory’s processing time and your healthcare provider’s request for follow-up.
Can IgG Antibodies Protect Me from Getting COVID-19 Again?
IgG antibodies provide some protection, but they do not guarantee immunity against reinfection. Protection may vary by individual and can decrease over time. Vaccination remains the most effective way to prevent COVID-19 and its severe complications.
Do IgG Antibody Levels Change Over Time?
Yes, IgG antibody levels can decline after infection or vaccination. They may remain detectable for months or years but can decrease gradually, which is why periodic testing may be recommended in certain situations, such as for research or high-risk individuals.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy