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SARS-CoV-2 Nucleic Acid Test (Qualitative, Plasma/Serum)

Published: August 9, 2026Updated: August 16, 2026

This test detects genetic material from the SARS-CoV-2 virus, which causes COVID-19, in your blood. It helps determine if you are currently infected with the virus.

Quick summary

["This test checks for active COVID-19 infection by looking for the virus’s genetic material in your blood sample."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
94756-4
Short code
SARS-CoV-2 N gene Resp Ql NAA N1
Synonyms
SARS-CoV-2 N gene Resp Ql NAA N1
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar-cdc-primer-probe-set-n
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test identifies the presence of SARS-CoV-2 genetic material (nucleic acid) in your plasma or serum. This is done through a molecular method, often called PCR (Polymerase Chain Reaction), which amplifies and detects tiny amounts of the virus’s DNA or RNA.

Why It’s Done

Your healthcare provider may order this test if you have symptoms of COVID-19, such as fever, cough, or shortness of breath, or if you’ve been exposed to someone with the virus. It can also be used to confirm a diagnosis in certain clinical settings.

Sample Collection and Preparation

A blood sample is taken from a vein, usually in your arm. The blood is processed to separate plasma or serum, which is then tested for the virus’s genetic material. This process is quick and typically done in a laboratory.

What to Expect Before the Test

No special preparation is usually needed for this test. You may be asked to fast before the blood draw if instructed by your healthcare provider, but this is not always required for nucleic acid testing.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

How long does it take to get results?
Results are typically available within 24 to 48 hours, depending on the laboratory’s processing time. Your healthcare provider will contact you with the results once they are ready.
Can I have this test if I’ve already been vaccinated?
Yes, you can still have this test even if you’ve been vaccinated. It helps determine if you are currently infected with COVID-19, regardless of your vaccination status. Vaccination reduces your risk of severe illness but does not prevent infection entirely.
What if my test is positive?
If your test is positive, you should isolate yourself from others to prevent spreading the virus. Follow your healthcare provider’s instructions for next steps, which may include further testing, treatment, or monitoring. Contact public health authorities if you have concerns about your results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy