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SARS-CoV-2 Nucleic Acid Detection by Qualitative Reverse Transcription Polymerase Chain Reaction (RT-PCR) on Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test checks for genetic material from the virus that causes COVID-19 in your blood. It helps determine if you have an active infection.

Quick summary

["This test helps doctors diagnose COVID-19 by detecting viral genetic material in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
94766-3
Short code
SARS-CoV-2 N gene SerPl Ql NAA+probe
Synonyms
SARS-CoV-2 N gene SerPl Ql NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

How the Test Works

The test uses a special probe designed to target the virus’s genetic material. When the probe finds the virus’s RNA, it triggers a reaction that produces a detectable signal, confirming the presence of the virus.

What to Expect Before the Test

No special preparation is needed. You may have blood drawn from a vein in your arm. If you’re feeling unwell, let your healthcare provider know before the test.

When This Test Is Used

Doctors may order this test if you have symptoms of COVID-19 (such as fever, cough, or shortness of breath) or if you’ve been exposed to someone with the virus. It can also be used for monitoring in certain clinical settings.

What the Results Mean

A positive result means the test detected viral genetic material, suggesting you may have an active COVID-19 infection. A negative result means the test did not detect the virus’s genetic material at the time of testing.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test plays a key role in diagnosing COVID-19 by confirming the presence of the virus in your blood. It helps guide treatment decisions and public health measures, such as isolation or quarantine recommendations.

Short name

SARS-CoV-2 RNA Test (Serum/Plasma)

Frequently asked questions

Why did my doctor order this test?
Your doctor may have ordered this test to check for COVID-19 symptoms, exposure risk, or as part of monitoring your health during or after a potential infection.
What does a positive result mean?
A positive result means the test found genetic material from the virus, indicating you likely have an active COVID-19 infection. Follow your doctor’s advice for next steps, such as treatment or isolation.
Can I get this test at home?
Most COVID-19 nucleic acid tests are performed in a clinical lab using blood samples collected by a healthcare professional. Home tests (like rapid antigen tests) detect different components of the virus and are not the same as this test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy