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SARS-CoV-2 Nucleic Acid Test (Qualitative, Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test detects genetic material from the virus responsible for COVID-19 in your blood. It helps determine if you have an active infection.

Quick summary

["This test checks for COVID-19 virus presence in your bloodstream."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
99596-9
Short code
SARS-CoV-2 N IgG SerPl Ql IA
Synonyms
SARS-CoV-2 N IgG SerPl Ql IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test looks for the virus’s genetic material (nucleic acids) in your blood, specifically from SARS-CoV-2. This is done using a molecular method that identifies fragments of the virus’s DNA or RNA. If these fragments are found, it suggests you may have an active COVID-19 infection.

How the Test Works

A small blood sample is taken and processed to extract viral genetic material. The test then uses a highly sensitive technique to detect these fragments, which are compared to known virus sequences. If the virus is present, the test will confirm it.

Why It’s Done

This test is often used to diagnose COVID-19, especially in people who are symptomatic or at higher risk of infection. It can also help monitor the progression of the disease or guide treatment decisions.

Sample Collection and Preparation

A healthcare provider will draw blood from a vein in your arm. The blood sample is then sent to a lab for processing. The test typically requires a fresh sample, though some labs may use stored samples if available.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

A positive result indicates the presence of SARS-CoV-2 nucleic acids, strongly suggesting an active COVID-19 infection. This can guide treatment decisions, such as starting antiviral therapy or isolating to prevent spreading the virus. A negative result means the virus was not detected in the sample at the time of testing, but it does not rule out infection if symptoms persist or if testing was done too early. Results should always be interpreted by a healthcare provider in the context of your symptoms and medical history.

Frequently asked questions

When Might I Get This Test?
This test is commonly ordered if you have symptoms of COVID-19, such as fever, cough, or difficulty breathing, or if you’ve been exposed to someone with the virus. It may also be used for screening in high-risk settings like healthcare facilities or before certain procedures.
How Long Does It Take to Get Results?
Results are usually available within 24 to 48 hours, depending on the lab’s processing time. Some labs offer same-day results for urgent cases, but this can vary by location and healthcare provider.
Can I Have False Results?
While rare, false results can occur due to sample contamination, improper handling, or early-stage infections where viral loads may be too low to detect. If you test negative but still feel sick, it’s important to consult your healthcare provider for further evaluation.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy