SARS-CoV-2 Nucleocapsid Protein (N) Qualitative Nucleic Acid Amplification Test (Upper Respiratory Specimen)

How the Test Works

The test uses a specialized probe to identify the virus’s genetic material (nucleocapsid protein) in your sample. If the virus is present, the test will detect it through a molecular amplification process, often called PCR (Polymerase Chain Reaction). This process makes many copies of the virus’s genetic material so it can be detected even in small amounts.

What to Expect During the Test

You will provide a sample of nasal or throat secretions (e.g., swab) to collect cells and virus particles. The sample is then sent to a lab where it is analyzed for the presence of the virus’s genetic material.

When the Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms of COVID-19 (e.g., fever, cough, shortness of breath) or if you have been exposed to someone with COVID-19. It can also be used for screening in certain settings, such as before returning to work or travel.

What the Results Mean

A positive result means the test detected the virus’s genetic material, indicating you likely have an active COVID-19 infection. A negative result means the test did not detect the virus’s genetic material at the time of testing, but this does not always mean you are not infected. Results may take several days to receive.