SARS-CoV-2 Nucleocapsid Protein Antigen Qualitative Test (Serum/Plasma)
This test detects antibodies to the nucleocapsid protein of SARS-CoV-2, the virus responsible for COVID-19. It helps identify if your immune system has recognized and responded to the virus.
This test can help determine past infection with COVID-19 by detecting antibodies in your blood.
Key facts at a glance
- LOINC
- 96899-0
- Short code
- SARS-CoV-2 ORF1ab Ct OPA wash Qn NAA+prb
- Synonyms
- SARS-CoV-2 ORF1ab Ct OPA wash Qn NAA+prb
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- probe-amp-tar
- CPT
- 86430
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The test looks for antibodies called nucleocapsid-specific immunoglobulins (IgG and IgM) that your body produces in response to the virus. These antibodies are produced after infection and can remain in your system for months or longer. The presence of these antibodies suggests exposure to the virus, though they may not always confirm a past infection if testing too soon after exposure.
How the Test Works
This is a qualitative immunoassay test performed on serum or plasma. It detects antibodies against the nucleocapsid protein of SARS-CoV-2 using a specific probe. The test result is either positive or negative, indicating the presence or absence of these antibodies.
When to Consider This Test
You may need this test if you have had symptoms of COVID-19, have been exposed to someone with COVID-19, or if you are part of a study or surveillance program. It can also be used in certain clinical settings to assess past infection status.
Limitations and Considerations
While this test can indicate past infection, it may not be accurate if taken too soon after exposure. False negatives can occur if testing is done before your body has had time to produce detectable antibodies. Additionally, some people may not develop detectable antibodies even after infection.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
This test is primarily used for serological screening and confirmation of past SARS-CoV-2 infection. It can be useful in epidemiological studies, for monitoring immunity in vaccinated individuals, and in certain diagnostic algorithms to support clinical decisions. However, it should not replace other diagnostic tests like PCR or antigen tests for current infection.
Short name
Nucleocapsid Antibody Screen
Frequently asked questions
When might I get a false positive or false negative result?
Can this test be used to confirm a recent COVID-19 infection?
Is this test the same as a COVID-19 vaccine antibody test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy