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SARS-CoV-2 Nucleic Acid Detection by Saliva Probe (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test checks for the genetic material of the virus that causes COVID-19 in your saliva. It helps determine if you have an active infection.

Quick summary

A positive result may indicate recent COVID-19 infection; a negative result does not rule it out entirely.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
98494-8
Short code
SARS-CoV-2 ORF1a Sal Ql NAA+probe
Synonyms
SARS-CoV-2 ORF1a Sal Ql NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
CPT
86430
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

How the Test Works

The test uses a special probe to detect the virus’s genetic material (RNA) in your saliva. A sample is collected, and the lab analyzes it using polymerase chain reaction (PCR) technology to identify the virus’s presence.

What to Expect Before the Test

No special preparation is needed. You may rinse your mouth with water before collecting the sample, but avoid eating, drinking, or smoking for at least 30 minutes beforehand.

Sample Collection Process

A healthcare provider will give you a swab to collect saliva. You’ll gently swab the inside of your cheek, and the sample is sent to the lab for testing.

Test Results and Interpretation

Results are typically reported as either positive (indicating active infection) or negative (no detectable virus). A negative result does not guarantee you are not infected, especially if symptoms persist.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is crucial for diagnosing COVID-19, guiding treatment decisions, and monitoring infection spread. It helps identify active cases for isolation and preventive measures.

Short name

SARS-CoV-2 RNA in Saliva (PCR Test)

Frequently asked questions

What does a positive result mean?
A positive result suggests you are likely infected with SARS-CoV-2 and may be contagious. Follow public health guidelines for isolation and care.
Can a negative result mean I don’t have COVID-19?
Not necessarily. A negative result means the virus was not detected in this sample, but infection could still be present. Symptoms or a positive test from another source may confirm diagnosis.
How soon after exposure can I get a positive result?
Results may take 24 to 72 hours, depending on lab processing. Some tests provide results sooner, but delays can occur due to lab workload.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy