SARS-CoV-2 RNA Sequencing (LNA Probe)

This test measures specific markers in your body that are associated with COVID-19, such as viral genetic material or antibodies, so your healthcare provider can determine whether you have a current infection or evidence of a past one.

The test analyzes a sample of your respiratory secretions (such as nasal or throat swab fluid) for the presence of SARS-CoV-2 RNA. The LNA (locked nucleic acid) probe binds specifically to unique viral genetic sequences, allowing for highly sensitive detection of the virus’s RNA. This method is used to identify active infection rather than past exposure.

The test works by collecting a small sample, usually a swab from your nose or throat or a small blood sample, which is then examined in a laboratory or with a rapid testing device to look for signs of the virus or your immune response to it.

During the test, a swab is collected from your nose or throat to gather cells and fluids containing viral RNA. The sample is then processed to extract and amplify the viral genetic material. The LNA probe targets specific viral sequences, and detection confirms whether the virus is present in your system.

This test is typically used when you have symptoms that could be caused by COVID-19, when you have been in close contact with someone who tested positive, or when you need documentation of your infection status for travel, work, school, or a medical procedure.

This test is typically ordered to diagnose active COVID-19 infection, especially when symptoms such as fever, cough, or shortness of breath are present. It may also be used in high-risk settings (e.g., healthcare facilities, long-term care) to monitor for outbreaks or in asymptomatic individuals who may have been exposed.

Before the test, your healthcare provider will explain how the sample will be collected and ask about your symptoms, recent exposures, and medical history. In most cases, no special preparation such as fasting is needed, but be sure to follow any specific instructions you are given.

No special preparation is needed. You may have a nasal or throat swab performed by a healthcare provider. The procedure is quick and generally painless. If you are taking certain medications or have allergies, let your provider know before the test.