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SARS-CoV-2 RNA Qualitative Nucleic Acid Amplification Assay (NAA) by Probe-Based Detection

Published: August 9, 2026Updated: August 16, 2026

This test detects genetic material from the virus that causes COVID-19 in a sample collected from you. It helps healthcare providers determine if you have an active infection.

Quick summary

["A positive result suggests possible COVID-19 infection; a negative result means the virus was not detected in this sample at the time of testing."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
96797-6
Short code
SARS-CoV-2 RNA OPA wash Ql NAA+probe
Synonyms
SARS-CoV-2 RNA OPA wash Ql NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

How the Test Works

The test uses a specialized probe to identify specific sequences of the SARS-CoV-2 virus’s RNA. When the virus is present, the probe binds to its genetic material, triggering a detectable signal that confirms infection.

What to Expect Before the Test

No special preparation is needed. You may collect a nasal or throat swab sample yourself or have it collected by a healthcare provider. Follow any instructions provided to ensure accurate results.

What to Expect During the Test

The sample is processed in a laboratory setting where genetic material is extracted and analyzed. The test result is typically available within 24 to 48 hours, depending on lab workflows.

What the Results Mean

A **positive result** indicates that the virus was detected in your sample, suggesting you may have an active COVID-19 infection. A **negative result** means the virus was not detected at the time of testing, but you may still be at risk of infection.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

SARS-CoV-2 RNA Test (Qualitative)

Frequently asked questions

Why might my healthcare provider order this test?
This test is commonly used to diagnose active COVID-19 infections, especially in individuals with symptoms like fever, cough, or shortness of breath. It is also used in screening, monitoring, or evaluating exposure risk in healthcare settings, schools, or community gatherings.
What if I have a positive result?
A positive result means you likely have an active COVID-19 infection. Follow your healthcare provider’s guidance on isolation, treatment, and monitoring. Report your results to anyone you may have been in close contact with to help prevent further spread.
How accurate is this test?
This test is highly sensitive and specific for detecting SARS-CoV-2 RNA, but results may vary based on sample quality, timing of testing, and viral load. False negatives can occur if testing is done too early after exposure, while false positives are rare but possible with laboratory errors or cross-contamination.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy