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SARS-CoV-2 RNA in Plasma/Serum (Qualitative, Nucleic Acid Amplification Probe-Based)

Published: August 9, 2026Updated: August 16, 2026

This test detects genetic material from the SARS-CoV-2 virus, which causes COVID-19, in your blood plasma or serum. It helps healthcare providers determine if you are currently infected.

Quick summary

["This test can confirm active COVID-19 infection by checking for the virus’s genetic material in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
94660-8
Short code
SARS-CoV-2 RNA SerPl Ql NAA+probe
Synonyms
SARS-CoV-2 RNA SerPl Ql NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test if you have symptoms like fever, cough, or shortness of breath, or if you’ve been exposed to someone with COVID-19. It can also be used to monitor certain groups at higher risk for severe illness.

How Is the Test Performed?

A blood sample is taken from a vein in your arm. The sample is then analyzed in a lab to detect the virus’s genetic material using a specialized probe-based technique.

What Does a Positive Result Mean?

A positive result means the test found genetic material from SARS-CoV-2, indicating you are likely currently infected with COVID-19. Follow your doctor’s guidance for treatment and isolation.

What Does a Negative Result Mean?

A negative result means the test did not detect the virus’s genetic material in your sample. However, it’s possible you could still be infected if the test was taken too early or if the virus is present in low amounts.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: This test is critical for diagnosing active COVID-19 infection. It helps guide treatment decisions, monitor high-risk patients, and control outbreaks by identifying cases early. Results may vary based on timing after exposure and viral load.

Short name

COVID-19 Nucleic Acid Test (Serum/Plasma)

Frequently asked questions

Can this test detect COVID-19 even if I feel well?
Yes, the test can detect the virus even if you don’t have symptoms. Some people may be infected but not show signs of illness until later.
How soon after exposure can I get a positive result?
Results may take a few days to appear after exposure. Symptoms may not appear until 2–14 days later, so testing early can help confirm infection before symptoms develop.
Is this test the same as a rapid antigen test?
No, this is a molecular (nucleic acid amplification) test that detects the virus’s genetic material, while rapid antigen tests detect viral proteins. Both can be used for diagnosis, but molecular tests are generally more sensitive.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy