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SARS-CoV-2 Nucleic Acid Detection by Reverse Transcription Polymerase Chain Reaction (RT-PCR) with Donor-Specific Probe

Published: August 9, 2026Updated: August 16, 2026

This test checks for the genetic material (RNA) of the virus that causes COVID-19 in a sample collected from you. It helps determine if you have an active infection.

Quick summary

["The test may help guide treatment decisions and monitor recovery from COVID-19."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
96829-7
Short code
SARS-CoV-2 RNA Spec Donr Ql NAA+probe
Synonyms
SARS-CoV-2 RNA Spec Donr Ql NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

How the Test Works

The test uses a process called reverse transcription polymerase chain reaction (RT-PCR) to detect the virus’s RNA. A special probe is designed to match the virus’s genetic sequence, allowing the test to identify its presence in your sample.

What to Expect Before the Test

No special preparation is needed. You may collect a sample (e.g., nasal swab, throat swab, or respiratory fluid) at home or during a clinic visit. Follow your healthcare provider’s instructions carefully.

Sample Collection and Processing

The sample is sent to a lab where it is processed to extract viral RNA. The lab then applies the RT-PCR method with a probe to detect the virus’s genetic material.

When You Might Need This Test

This test is commonly used for diagnosing active COVID-19 infections, especially when symptoms appear or after exposure. It may also be used for screening in high-risk settings or during outbreaks.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

SARS-CoV-2 RNA Test (PCR)

Frequently asked questions

Why might my healthcare provider order this test?
Your provider may order this test to confirm a suspected COVID-19 infection, assess your risk of spreading the virus, or monitor your recovery. Results can guide decisions about isolation, treatment, or further testing.
What do my results mean?
A positive result indicates the presence of the virus’s RNA, suggesting an active infection. A negative result means the virus was not detected in the sample at the time of testing, but false negatives can occur. Follow-up testing may be recommended if symptoms persist.
How long do results take?
Results are typically available within 24 to 72 hours, depending on lab processing times. Your healthcare provider will contact you with the results once they are ready.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy