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SARS-CoV-2 RNA (Nucleic Acid Amplification Probe) Test

Published: August 9, 2026Updated: August 16, 2026

This test detects genetic material from the virus responsible for COVID-19 in a sample collected from your respiratory system.

Quick summary

["This test helps determine if you have an active COVID-19 infection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
94819-0
Short code
SARS-CoV-2 RNA Spec NAA+probe-Log#
Synonyms
SARS-CoV-2 RNA Spec NAA+probe-Log#
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

How the Test Works

The test uses a specialized probe to identify specific genetic sequences unique to the SARS-CoV-2 virus. When the probe binds to these sequences in your sample, it triggers a signal that confirms the presence of the virus.

What to Expect During the Test

You will provide a nasal or throat swab sample. The sample is then processed in a laboratory to detect viral RNA. Results are typically available within 24 hours.

Why This Test Matters

Identifying active COVID-19 infection is crucial for managing your health, preventing spread, and guiding treatment decisions.

Common Uses

This test is commonly used for diagnosing active COVID-19 infections, monitoring recovery, and assessing exposure risk in healthcare and community settings.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Frequently asked questions

What does a positive result mean?
A positive result indicates the presence of SARS-CoV-2 RNA, suggesting you are likely infected with COVID-19 at the time of testing. This may require isolation, treatment, and follow-up care.
What does a negative result mean?
A negative result means the test did not detect SARS-CoV-2 RNA in your sample. However, it is possible you could still be infected if tested too early or if the virus is present at very low levels. Follow-up testing may be recommended if symptoms persist.
How accurate is this test?
This test is highly sensitive and specific for detecting active COVID-19 when performed correctly. However, like any test, it may have limitations, such as false negatives if taken too early in the infection or if the sample is not representative.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy