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SARS-CoV-2 Genomic Sequence Detection by Targeted Probe Amplification (Nucleocapsid Protein)

Published: August 9, 2026Updated: August 16, 2026

This test detects genetic material from the SARS-CoV-2 virus, the cause of COVID-19, using a specialized molecular method. It helps confirm infection by identifying unique viral sequences.

Quick summary

["This test checks for the virus that causes COVID-19 by analyzing a small sample of your bodily fluid."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
96900-6
Short code
SARS-CoV-2 S gene Ct OPA wash Qn NAA+prb
Synonyms
SARS-CoV-2 S gene Ct OPA wash Qn NAA+prb
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

How the Test Works

The test uses a molecular technique to identify specific genetic sequences in your sample. It targets a part of the virus’s nucleocapsid protein, which is unique to SARS-CoV-2. If the virus is present, the test can detect its genetic material.

Sample Collection

You will provide a nasal or throat swab sample, similar to a rapid COVID-19 test. This sample is then processed in a lab to extract viral genetic material for testing.

What to Expect Before the Test

No special preparation is needed for this test. You may have a rapid COVID-19 test done at the same time, or your sample may be sent to a lab for further analysis. If you’re taking medications or have recent medical conditions, let your healthcare provider know.

When Results Are Needed

Results from this test are typically available within a few days, depending on lab processing times. Your healthcare provider will discuss the results with you and guide next steps, such as isolation or treatment recommendations.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test plays a critical role in diagnosing active COVID-19 infection. Positive results confirm the presence of the virus and help guide treatment, isolation, and public health measures. Negative results may still be possible if the virus is present but not detected at the time of testing or if the sample was collected too early.

Short name

Nucleocapsid Probe Amplification Test

Frequently asked questions

Why did my doctor order this test?
Your doctor may have ordered this test to confirm a suspected COVID-19 infection, especially if symptoms are present or if you’ve been exposed to someone with the virus. It can also be used in ongoing monitoring for patients recovering from COVID-19 or in research settings.
What does a positive result mean?
A positive result means that the test detected genetic material from the SARS-CoV-2 virus, indicating an active infection. This usually means you have COVID-19 and should follow guidance on isolation, treatment, and monitoring from your healthcare provider.
Can I get this test at home?
This test is typically performed in a clinical or laboratory setting. While rapid at-home COVID-19 tests exist, this specific test requires specialized lab equipment and processing. Your healthcare provider will guide you on where to get this test done.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy