SARS-CoV-2 Spike (S) Receptor Binding Domain (RBD) Nucleic Acid Test, Plasma/Serum

How the Test Works

The test uses advanced molecular techniques to search for the virus’s genetic material (nucleic acid) in your sample. If the virus is present, the test can detect its unique genetic sequence, including the RBD portion of the spike protein, which plays a key role in how the virus attaches to human cells. This helps confirm infection at the time of testing.

What to Expect Before the Test

No special preparation is needed. You may have a blood draw (plasma or serum) or a similar procedure, depending on your healthcare provider’s protocol. If you’re using a saliva sample, follow any instructions provided to ensure accuracy.

When This Test Might Be Used

Your healthcare provider may order this test if you have symptoms of COVID-19 (e.g., fever, cough, fatigue), have been exposed to someone with the virus, or are part of a screening or monitoring program. It can also be used to confirm a positive result from an antigen test.

Limitations and Considerations

This test detects viral genetic material but does not measure antibody levels (which indicate past infection or immunity). Results may be affected by factors like recent treatment, sample handling, or viral load at the time of testing. False negatives can occur if testing happens too early after exposure.