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Serum SARS-CoV-2 IgG Antibody (Immunoassay)

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of IgG antibodies in your blood that your immune system produces in response to exposure to the SARS-CoV-2 virus, which causes COVID-19. IgG antibodies are part of your body’s long-term immune defense.

Quick summary

["IgG antibodies indicate past infection or vaccination immunity to COVID-19."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
41460-7
Short code
SARS-CoV IgG Ser Ql IA
Synonyms
SARS-CoV IgG Ser Ql IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

IgG antibodies are a type of antibody your immune system creates after recovering from COVID-19 or after vaccination. They provide long-term protection by helping your body recognize and fight the virus if you become infected again. This test detects these antibodies in your serum, which is the liquid part of blood after clotting.

Why Might You Need This Test?

Doctors may order this test to confirm past infection with COVID-19, assess immunity after vaccination, or evaluate immune response in certain medical conditions. It can also help determine if someone has developed immunity over time.

How Is the Test Performed?

A blood sample is taken from a vein in your arm. The sample is sent to a lab where it is analyzed using an immunoassay method to detect IgG antibodies specific to SARS-CoV-2.

What Are Common Results and Their Meanings?

A positive result suggests you have developed IgG antibodies, indicating either past infection or vaccination-induced immunity. A negative result means the test did not detect these antibodies, which may mean you haven’t developed immunity yet or have been exposed recently.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Understanding Your Results

Short name

IgG Antibody to SARS-CoV-2

Frequently asked questions

Why was this test ordered for me?
Your doctor may have ordered this test to check if you have developed immunity to COVID-19, monitor your immune response after vaccination, or assess your risk of infection if you’ve had exposure. It’s also used in research or clinical studies to track immunity over time.
What does a positive result mean for my health?
A positive result means your body has produced IgG antibodies, which generally indicate a strong immune response. This doesn’t guarantee you can’t get sick again, but it shows your body has some level of protection. Follow your doctor’s advice on precautions.
Can I still get COVID-19 if my test is positive for IgG antibodies?
Yes, while IgG antibodies provide some protection, they don’t make you immune to infection. New variants of the virus can sometimes evade immunity, and other factors like age or health conditions may affect your risk. Stay informed about vaccination updates and preventive measures.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy