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SARS-CoV-2 Nucleic Acid Detection in Upper Respiratory Specimen (Qualitative PCR)

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of genetic material from the virus that causes COVID-19 in your upper respiratory tract, such as a nasal swab or throat swab.

Quick summary

["Determines if you have an active COVID-19 infection by detecting the virus’s genetic material."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
96122-7
Short code
SARS-rel CoV E gene Upper resp Ql NAA+prb
Synonyms
SARS-rel CoV E gene Upper resp Ql NAA+prb
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

How the Test Works

The test uses a specialized laboratory technique called polymerase chain reaction (PCR) to identify tiny pieces of the virus’s genetic code. A small sample of your upper respiratory secretions is collected and analyzed to detect the virus’s genetic material, even if you’re not yet showing symptoms.

What to Expect Before the Test

You may be asked to avoid eating, drinking, or using mouthwash for a short time before the test. Your healthcare provider will give you specific instructions based on your situation. The test typically involves a quick, painless swab of your nose or throat.

What to Expect During the Test

The procedure is quick and usually done in a doctor’s office, clinic, or testing center. You may feel mild discomfort from the swab, but it’s not invasive. The sample is then sent to a lab for analysis.

When You Might Need This Test

This test is often recommended if you have symptoms of COVID-19, such as fever, cough, or shortness of breath, or if you’ve been exposed to someone with the virus. It may also be used for screening in settings like schools, workplaces, or community gatherings.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

COVID-19 Upper Respiratory PCR Test

Frequently asked questions

Why might I get this test?
Your healthcare provider may recommend this test if you have symptoms of COVID-19, have been exposed to someone with the virus, or are in a setting where testing is required for safety reasons.
What does a positive result mean?
A positive result means the test detected the virus’s genetic material in your sample, indicating you are likely infected with COVID-19 at the time of testing. You should follow isolation guidelines and consult your healthcare provider about next steps.
Can a negative result mean I don’t have COVID-19?
A negative result means the virus’s genetic material was not detected in your sample at the time of testing. However, it’s possible you could still be infected if you were exposed recently. If you develop symptoms later, you may need to get tested again.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy