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Staphylococcus aureus Detection by Nucleic Acid Probe (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of genetic material from *Staphylococcus aureus*, a common bacteria that can cause infections like skin infections, pneumonia, or bloodstream infections. It’s used to confirm infection when symptoms are present or when cultures are inconclusive.

Quick summary

["A simple, fast test to help diagnose *Staphylococcus aureus* infections without needing lab culture results."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
85764-9
Short code
S aureus+CoNS DNA Bld Pos NAA+non-probe
Synonyms
S aureus+CoNS DNA Bld Pos NAA+non-probe
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
non-probe-amp-tar
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

How the Test Works

The test uses a specialized probe to detect genetic material (DNA) from *Staphylococcus aureus*. A small sample of blood, swab, or other bodily fluid is collected and analyzed to see if the bacteria’s DNA is present. If the probe binds to the DNA, it confirms infection.

What to Expect Before the Test

No special preparation is needed for this test. You may have a blood draw, a swab of a sore or wound, or a urine sample collected depending on the type of infection suspected. If you’re taking antibiotics, let your provider know, as this may affect results.

What the Results Mean

A positive result means the test detected *Staphylococcus aureus* DNA, suggesting an infection caused by this bacteria. A negative result means no DNA was found, but this doesn’t always rule out infection—other causes or less common bacteria may be present. Follow-up testing or treatment may still be needed.

When You Might Need This Test

Your doctor may order this test if you have symptoms like fever, redness, pain, or drainage from a wound, or if you’re showing signs of a systemic infection (like pneumonia or sepsis). It’s also used in settings like hospitals or long-term care facilities to monitor for infections in patients who are at higher risk.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Staph aureus DNA Probe Test

Frequently asked questions

Why is this test important?
This test provides a quick and reliable way to confirm *Staphylococcus aureus* infections without waiting for lab cultures, which can take days. Early identification helps your doctor choose the right treatment, such as antibiotics, to stop the infection and prevent complications.
Can false results happen?
Yes, false results can occur, especially if the sample isn’t collected correctly or if the bacteria isn’t actively growing. False negatives may happen if the bacteria isn’t present in the sample taken. False positives are rare but can occur if other bacteria or contaminants are mistaken for *Staphylococcus aureus*.
How long does it take to get results?
Results are typically available within 24 hours or less, depending on the lab and testing method. Your doctor will discuss the results with you and decide next steps, such as starting antibiotics or continuing monitoring.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy